CURRENT STEM CELL NEWS

1. Protein associated with cancer helps stem cells maintain pluripotency – reveals study

BRD4 is a protein known to be associated with several cancers and a potential target in several therapeutic trials. It has now been identified that BRD4 by occupying the super-enhancer sites of genes helps in the maintenance of stem cell identity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Chemical found in turmeric boosts neural regeneration – potential to be used in treating neurodegenerative diseases

A study has reported that Aromatic (ar-) turmerone, a compound found in turmeric when added to neural stem cells in vitro or inside rat brains, it stimulated the stem cells to produce more neurons compared to the control. If this study is proven in humans it will help to treat neurodegenerative diseases like Alzheimer's disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Tonsil derived stem cells in thermogel matrices may help to treat liver damage

Tonsil derived mesenchymal stem cells have been induced to differentiate into liver cells by growing them in 3D thermogel matrices in a recent study. This 3D system can be used for liver tissue regeneration in the future . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. iPS cell model system used to study genetic mutation causing heart disease

A mutation in the gene that encodes for an enzyme ALDH2 leads to an increased risk of heart disease. Using iPS cell model systems from people with and without mutations, researchers have observed that the mutations affects heart health by controlling the survival decisions taken by the heart cells during stress. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Mechanisms behind cure in HIV patient after Stem cell transplant explored using Simian/Human Immunodeficiency Virus (SHIV) monkeys

Stem cell transplant from a donor with CCR5 mutation helped a HIV patient get cured in a study done last year. Now scientists have tested a similar strategy but with autologous stem cell transplant in monkeys infected with simian/human immunodeficiency virus (SHIV). However the viral reservoir continued to persist in the monkey after the transplant. Thus researchers feel the cure in the human could be due to a donor with CCR5 mutation or a "graft versus host" response. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Pluripotent Stem cells reset to their earliest state – Potential to develop newer therapies

Human pluripotent stem cells have been reverted to a more stable ground state of pluripotency using various chemicals and biological factors. These reset stem cells could now be comparable to totipotent embryonic stem cells which could be used in various studies for developing newer therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Molecule that enhances umbilical cord blood stem cell proliferation reported

Researchers have employed a new method involving a molecule called UM171 to boost the stem cells in umbilical cord blood as these stem cells are highly useful for life saving stem cell transplants in diseases such as leukaemia and other blood related cancers. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Stem cell research sheds new light on chemical basis for schizophrenia

Human induced pluripotent stem cells from Schizophrenia patients when studied in the lab showed that the neurons from these stem cells secreted higher amount of certain neurotransmitters which could be attributed to the disease activity in such patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Stem cells communicate with the microenvironment via fluid filled bags like vesicles - identifies study

A study has reported that grafted stem cells communicate to the nearby host immune cells via fluid filled bags called vesicles and thus help regulate immune responses in their vicinity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. First patient of first ever iPS clinical trial for age-related macular degeneration (AMD) transplanted with iPS derived cells

In the first ever clinical trial on induced pluripotent stem (iPS) cells for age-related macular degeneration (AMD), the first patient of the trial, a female has received the graft of retinal pigment epithelial (RPE) cells derived from the iPS. Click to read more...

Really???

1. Did you know that in the 1900s when RNA and DNA were isolated, they were known after the sources from which they were isolated, RNA as "Yeast nucleic acid" and DNA as "pancreas nucleic acid"? Later when carbohydrate chemists identified the differences in the sugar molecules in these nucleic acids they became to be known as Ribonucleic acid (RNA) and Dexoyribonucleic acid (DNA) respectively. - Source : Wikipedia

2. Are you aware that Emil Adolf von Behring was the first Nobel Prize recipient for Physiology and Medicine? He was awarded the Nobel Prize in 1901 for his work on serum therapy especially its application against Diphtheria. As of 2013, 104 Nobel prizes in Physiology and Medicine have been awarded to 204 Laureates.- Source: Nobelprize.org

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