CURRENT STEM CELL NEWS

1. Allogenic Stem cells work well than Autologous in Diabetic retinopathy – reveals study

In a study on injection of adipose derived stem cells (ASCs) for Diabetic retinopathy in rats researchers have found that ASCs derived from diabetic mice were functionally impaired compared to ASCs from non-diabetic mice thus supporting the use of allogenic cells for the condition rather than Autologous. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Specialized Progenitor cells committed to heart muscle cell formation identified

A recent work has identified an intermediate cardiac progenitor cell that expresses the marker Hopx which is committed exclusively to form cardiac muscle cells and this work will lead to progress in the research on cardiac regenerative therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. MicroRNA pre-treated stem cells and bio-degradable nanofibre patch to boost heart repair

When Mesenchymal Stem Cells (MSCs) were induced using a molecule to produce a microRNA called miRNA-133a, these MSCs upon transplantation into an animal model of cardiac ischemia showed improved survival compared to non-treated MSCs. In another study which also aimed to improve cell survival after transplantation, seeding human induced pluripotent derived cardiomyocytes on a biodegradable nanofiber patch led to cardiac tissue formation which was more similar to the native tissue compared with cells cultured on a flat surface. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal| Click here to view the link of the relevant publication in a peer reviewed journal

4. Cell surface modification using protein to promote lab engineering of large organs

As a method to improve the regeneration of bones and cartilage, human mesenchymal stem cells (hMSCs) have been pre-treated with artificial membrane-binding proteins which can act as a reservoir of oxygen for these cells when they perform their function of regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Neural stem cells are pre-programmed – says study

Contrast to the existing belief that neural stem cells have the ability to give rise to the different types of brain cells, a study in mice has identified that the neural stem cells are pre-programmed before birth to generate specific types of neurons. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Functionally distinct daughter cells controlling blood production identified

Scientists have studied the characteristics of multipotent progenitors (MPPs) which arise from the blood stem cells to form the entire blood system. Understanding their characteristics will help to optimize the blood forming ability of these cells for use in blood disorders. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Role of AIM2 in intestinal stem cell proliferation and colorectal cancer development studied

Scientists have discovered that an immune system protein called AIM2 plays an important role in protecting against colon cancer development and its deficiency causes uncontrolled proliferation of the intestinal stem cells. AIM2 also has been found to influence the gut microbiota. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Study sheds light on Tuberculosis bacteria's ability to hide in low oxygen stem cell niches

Mycobacterium tuberculosis bacteria use a specialized phenotype of bone marrow stem cells called CD271+ bone marrow–mesenchymal stem cells (BM-MSCs) in low oxygen (hypoxia) zones to hide, according to a new study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Hypoxia fate mapping technique identifies cycling heart muscle cells

By using a novel cell lineage-tracing technique called hypoxia fate mapping, researchers have identified that it is the hypoxic cardiomyocyte cells that replenish the adult heart muscle. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Role of Nucleoporins in embryonic stem cell pluripotency uncovered

Nucleoporins which are associated with nuclear transport across the nuclear envelope have now been proven to play additional role such as maintaining embryonic stem cell pluripotency by functioning in epigenetic gene silencing. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that the mother's vaginal microbiome acts as a primary source for the offspring's normal gut microbial colonization, host immune maturation, and metabolism when the offspring is exposed to the vaginal microbiome during parturition? As these interactions occur during a critical window period of neurodevelopment, maternal stress which leads to alterations in the vaginal microbiome may predispose the offspring to neurodevelopment disorders.     
 - Source: Jašarević E et al. Endocrinology, June 2015 and Science Daily article June 16, 2015

2. Did you know that a study on twins has shown that it is our genes which determine our likelihood of being bitten by mosquitoes? Attractiveness of mosquitoes is based on the differences in volatile chemicals produced by the human body which in turn have been found to have an underlying genetic component that can be detected by mosquitoes by olfaction.    
                                                     - Source: Fernández-Grandon GM et al. PLoS ONE 10(4): e0122716.

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