CURRENT STEM CELL NEWS

1. Novel method targeting CD47 to turn-on pluripotency in cells

As an alternative to the use of feeder layers and viral vectors to turn on pluripotency in cells and stem cells, researchers have devised a novel method which blocks the CD 47 molecule thereby make it possible to generate these cells in large numbers for therapies. Click to read more...

2. Direct reprogramming of skin cells to create oligodentrocyte precursor cells – Potential therapies for multiple sclerosis in the horizon

Scientists from Stanford have been able to create oligodendrocyte precursor cells (OPCs) directly from skin cells. These OPCs are the cells that wrap the nerve cells in the insulating myelin sheaths which are essential for nerve impulse transmission. This would help in designing therapies for conditions like multiple sclerosis, inherited leukodystrophies etc. Click to read more...

3. Clinical trial using Cardiopoietic cells for heart failure shows promising results

A phase II Clinical trial in Belgium has employed Cardiopoietic cells (mesenchymal stem cells exposed to cardiogenic cocktail) on 48 patients with stable heart failure and the outcome has been found to be significant along with safety of the procedure established.Click to read more...

4. Stem cell based gut healing in fruit flies fluctuates according to the time of day- identifies study

It has been identified that stem cell based intestinal regeneration in the fruit fly is rhythmic and is regulated by the circadian clock; i.e the regeneration is very active during certain times of the day. Click to read more...

5. Shock waves to boost efficacy of bone marrow-derived mononuclear cells (BMCs) in treating chronic heart failure

According to a study recently published, pre-treatment with cardiac shock waves before intra-coronary infusion of bone marrow-derived mononuclear cells (BMCs) will aid in improvement of heart function in patients with chronic heart failure. Click to read more...

6. Embryonic stem cell therapy restores brain function in mice

In a first of its kind study, human embryonic stem cells (hESCs) transformed to neural cells have been shown to successfully implant in the brain of mice and these cells have helped the mice regain the ability to learn and remember. Click to read more...

7. Lab grown Antibody to covert bone marrow stem cells to neural precursors

Scientists at The Scripps Research Institute (TSRI) have identified a new lab-grown antibody that not only activates the GCSF receptor thereby making bone marrow stem cells proliferate but they also found that this antibody helps in development of neural precursors directly from the bone marrow stem cells. Click to read more...

8. Novel method to separate pluripotent stem cells from differentiated cells identified- Hopes to create safer stem cell therapies

Pluripotent stem cells among a group of differentiated cells pose the threat of teratoma after in vivo infusion in therapies. Researchers have developed a novel molecule based method to block the proliferation of the pluripotent stem cells alone by triggering apoptosis in these cells leaving the differentiated cells unaffected. Click to read more...

9. Retinal pigment epithelial cells as a tool to address macular degeneration- an in-depth review

An in-depth review recently published on choice of cell sources for age related macular degeneration (AMD) depending on grade of damage to the retinal layers has outlined retinal pigment epithelial cells, which are in clinical trials already, as a potential cell source to address this condition. Click to read more...

10. Study uncovers key protein molecule behind follicular stem cell maintenance and differentiation in ovary of fruit flies

A study that has revealed the key protein which helps in maintaining follicle stem cells in the ovary of fruit flies and the fate determination of their progeny has thrown light on this previously poorly understood area in developmental biology. Click to read more..

11. Identification of a specific population of blood circulating tumor cells from breast cancer patients that initiates metastasis accomplished

In a breakthrough study, researchers have detected metastasis initiating circulating cancer cells characterized by three surface markers in the blood of breast cancer patients. Click to read more..

Really???

1. Did you know that large organs like the thigh have much smaller representations in the brain’s motor cortex while the thumb which is very small actually has a large representation in the brain due to its complex functions?

2. Have you heard about gender determination by temperature? It happens in certain animals like the alligators and the turtles. For eg. In some turtles which undergo Temperature-dependent sex determination (TSD) male offsprings are produced at cooler incubation temperatures ranging between 22.5 and 27 degrees Celsius while at warmer incubation temperatures around 30 degrees Celsius only female turtles are produced.

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