CURRENT STEM CELL NEWS

1. Long term culture of circulating breast cancer cells accomplished

Circulating cancer cells are the key players behind cancer Metastasis. A team of researchers have been able to successfully grow the circulating breast cancer cells in the laboratory for more than six months and this study will help in the study of new mutations and susceptibility of the cells to drugs in the future. Click to read more...

2. Transcription factors to directly convert human stem cells into the hemogenic endothelial cells reported

Researchers have directly derived hemogenic endothelial cells from human pluripotent stem cells using a novel technique that employs two distinct transcriptional factors. This technique is relatively safe as it does not involve the use of viruses. Click to read more...

3. Patient-specific models for retinitis pigmentosa (RP) created using iPS technology

Using iPS technology a team of researchers have transformed skin cells taken from two retinitis pigmentosa (RP) patients (each with a different type of mutation in the MFRP gene) to retinal cells. The scientists have then corrected the faulty gene in these retinal cells and used them to rescue mice with RP due to MFRP mutations. Click to read more...

4. Mechanism behind differentiation of Schwann cells (SCs) from Hair follicle-derived neural crest stem cells (NCSCs) deciphered

Studying the neural crest stem cells (NCSCs) from the hair follice it has been demonstrated that these cells can be induced to differentiate into Schwann cells (SCs) by employing novel molecules such as the micro RNA agonists.Click to read more...

5. Dental Stem Cells to Promote Retinal Regeneration

Dental pulp stem cells have been shown to protect retinal ganglion cells from death as well as promote the regeneration of their axons by secreting several neurotrophic factors.Click to read more...

6. Single cell technique helps study epigenetic changes controlling embryonic development

A powerful single-cell technique has been developed which can map all the 'epigenetic marks' on the DNA within a single cell and this can be useful in the study of the effects of the environment on the human development and on the inheritable traits. Click to read more...

7. Smooth muscle cells modified using Interleukin-10 improves heart function in rats with myocardial infarction

In rats modeled with myocardial infarction (MI) it has been proven that has shown that smooth muscle cells (SMCs) modified with the anti-inflammatory protein (IL-10) has helped in improving heart function and has also provided protection against the host's rejection.Click to read more...

8. Study establishes ASF1A as key gene responsible for the mechanism of cellular reprogramming

A new research that has analyzed nearly 5000 genes has reported that the gene called ASF1A along with another gene known as OCT4 and a helper soluble molecule are the ones responsible for cellular reprogramming. Click to read more...

9. Role of SOX4 in ageing, stem cell function and cancer revealed

Researchers had been finding it difficult to study the role of the important gene Sox 4 gene in an adult organism because the mice with eliminated Sox 4 die before birth. Now using a innovative technique scientists have been able to study the Sox 4 in adult mice and they have observed that mice with decreased Sox 4 exhibit premature loss of tissue maintenance, accelerated aging but increased cancer resistance. Click to read more...

10. Study reports biomarker for inner ear stem cells – Hopes to advance research on hearing disorders

A Polysialylated glycoprotein involved in the regulation of neurodevelopment has been identified to be present on the surface of the cells in the adult inner ear. This glycoprotein can serve as a biomarker to isolate neural stem cells from the adult inner ear for use in treating hearing disorders. Click to read more...

Really???

1. Are you aware that the major changes in the pigmentation of skins of humans from dark-skinned to light-skinned and vice versa (due to migration to different UV zones) occurred only over the last 100 generations (~2,500 years) through a process known as Selective sweeps? Selective Sweeps is a genetic process by which there is reduction or elimination of variation among the nucleotides in the neighboring DNA of a mutation due to recent and strong positive natural selection. (Source: Wikipedia)

2. Did you know that some reports have suggested that though moderate exercise is beneficial, prolonged bouts of strenuous exercise may actually cause a temporary depression of the various aspects of immune function including neutrophil respiratory burst, lymphocyte proliferation and monocyte antigen presentation. This dysfunction is more pronounced when the exercise is performed without food intake and is of continuous nature. This dysfunction though may compromise resistance to common minor illnesses it does not affect the long-term health benefits of regular exercise which is mediated through anti-inflammatory effects cytokines and/or by downregulation of toll-like receptor expression.  (Source : Gleeson. Immune function in sport and exercise. Journal of Applied Physiology 2007. DOI: 10.1152/japplphysiol.00008.2007)

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.