CURRENT STEM CELL NEWS

1. Study reports long term safety of embryonic stem cells in human patients with retinal diseases

A recent study has demonstrated the three year safety of human embryonic stem cell transplantation in 18 patients with retinal disease. The transplantation also improved vision in 10 of the study patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. New methodology helps extract bone cells with improved osteogenic potential from fat cells

A team of scientists has developed a new method for identifying and extracting potential bone-producing cells from fat cells. The cells are looked for expression of a gene called ALPL using a fluorescent tag, as this gene is an indicator of the bone making potential of these cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Endothelial colony-forming cells derived from iPS used to treat damaged blood vessels in limbs and retina of mice

Endothelial colony forming cells similar to ones found in the umbilical cord blood have been derived from human pluripotent stem cells using a new protocol and these cells have the capacity to repair ischemic limbs in mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Genetic mapping reveals mechanism by which brain produces new nerve cells after a stroke

It has been shown using genetic mapping studies that after a stroke, cells called astrocytes in the brain around the lesion of the stroke form immature nerve cells which then develop into mature nerve cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Stem cells in Esophagus identified

By studying pieces or "organoids" of esophageal tissue from mouse samples, researchers have reported that the esophagus has its own pool of stem cells which help in the renewal of the esophageal lining. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Unexpected link between gene associated with speech and metastasis of breast cancer revealed

A study has identified that mesenchymal stem cells cause aberrant expression of certain microRNAs whose activity represses the expression of a gene called FOXP2 involved in regulating speech and language development and this repression of FOXP2 initiates breast cancer metastasis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. In vitro grown 'organoids' of functioning human intestinal tissue transplanted to mice

Induced pluripotent stem cells (iPSCs) have been used to create 'organoids' of human intestinal tissue which when engrafted into the capsule of the kidney of a mouse, grew into fully mature human intestinal tissue. These organoids can be used as models for drug testing. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Cell based therapies for Spinal cord injury explored

Two recent studies have highlighted the use of stem cells to treat spinal cord injury (SCI). One study has analyzed the expression profile of receptors on multipotent stem cells called ependymal progenitor cells (epSPCs) and their role in spinal cord injury. The other study has demonstrated the efficacy of transplanted Autologous bone marrow cells (ABMCs)into dogs modeled with SCI. Click to read more... |Click here to view the link of the relevant publication in a peer reviewed journal | Click here to view the link of the relevant publication in a peer reviewed journal

9. Genetically engineered toxin resistant cancer stem cells - Potential to treat brain tumors

Stem cells have been genetically engineered to secrete toxins which have the ability to kill brain tumors. These stem cells were surrounded in gel and placed at the site of the brain tumor in mice and the tumors were destroyed. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Stem Cells from nose help treat spinal cord injured patient

A paraplegic patient who was transplanted cells called olfactory ensheathing cell (OEC) from the nose has shown dramatic recovery and is able to live more independently according to a recent report. Click to read more...

Really???

1. Are you aware about Junk DNA? Junk DNA refers to portions of a genome sequence for which no discernible function has been identified so far. These junk DNA have their origins in selfish amplification of transposable elements and though these have no proven phenotypic function, their ability to survive in the genome by evolving strategies itself makes no explanation necessary for their existence. This was postulated by W.Ford Doolittle and Carmen Sapienza in 1980's. According to the ENCODE project in 2012, over 80% of the human genome is biochemically functional. Earlier it was thought that nearly 98% of the human genome is junk DNA.

2. Do you know what a Transcriptome is? It is total set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA produced in one or a population of cells. Analysis of Transcriptome helps in understanding molecular pathways.

                                                                                                                            - Source: Wikipedia

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