CURRENT STEM CELL NEWS

1. iPS cell based vaccine to treat cancer

Irradiated iPSCs have been used as adjuvant in autologous anti-tumor vaccines which prevented tumor growth in breast cancer, mesothelioma, and melanoma models. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Dynamics of rDNA loci and aging of stem cells

The dynamic changes in unstable genetic elements known as ribosomal DNA (rDNA) loci during aging in the fruit fly germline stem cell (GSC) has been investigated which has thrown remarkable insights into the aging process. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Stem cell derived extracellular vesicles help treat stroke

Extracellular vesicles (EVs) derived from Neural stem cell (NSC) created from a pluripotent stem cell (PSC) line has helped in Improving the tissue and functional recovery in a stroke model in rats. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Self-assembling scaffolds to help study muscle fibre formation from precursor cells in vitro

Natural biomacromolecules have been coaxed to functionalize into self-assembled peptide (SAP) hydrogels on which when muscle precursors were grown, their morphology was altered. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Sheep-human hybrids developed to create organs for transplantation in humans

In order to make more organs available for transplantation, scientists have have created the second successful human-animal hybrids in which sheep embryos that are 0.01-percent human by cell count have been developed.Click to read more...

6. Synthetic ligand makes isolation of cancer stem cells easier

From nearly 40,000 chemical compounds in a chemical library, scientists have been able to to find out one ligand which can bind to the breast cancer stem cells that can easily isolate them from the surrounding normal breast cells and breast cancer cells that are not aggressive in nature. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Complex bioactive scaffolds to bioprint multiple cell types

A novel bio fabrication platform using peptide amphiphiles has been developed which can help to encapsulate and print multiple cell types in different spatial dimensions. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. RNA interference (RNAi) technology to help improve vascular grafts created from allogeneic cell sources

By using RNA interference (RNAi) technology to silence an immune-stimulating complex in endothelial cells (EC), it is possible to tissue engineer vascular grafts from allogeneic cell sources without the risk of immune rejection after transplant. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Neuron formation from stem cells imaged live in mouse brain

Scientists have been able to track genetically labeled individual neural stem and progenitor cells (NSPCs) and the neurons produced from them in the mouse hippocampus for up to 2 months. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Small molecule based articular cartilage repair reported

Using a a small molecule to alter the signalling through a molecule called glycoprotein 130 has helped scientists to increase proliferation of mesenchymal cells in the cartilage defect and to stop the breakdown of cartilage matrix in the newly generated cartilage in a rat model of cartilage defect. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. A study has established a link between genes and the snacks chosen by pre-schoolers. The study showed that 80% of the children studied had inherited genetic variants from their parents that could predispose them to poor snacking habits.
 -Source: ScienceDaily, 22 February 2018 and Nutrients 2018, 10(2), 153; doi:10.3390/nu10020153

2. Unravelling the mystery behind how multi-cellular species originated, a study has showed evidence that genes already present in the unicellular ancestor might have duplicated to form new genes with new functions that gave rise to multicellularity. The study also identified that among genetic processes, it was the ubiquitin proteasomal pathway (UPP) that played a key role in the evolution of multicellularity.     
-Source: ScienceDaily, 2 February 2018 and Molecular Biology and Evolution, 2017; DOI: 10.1093/molbev/msx332

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