CURRENT STEM CELL NEWS

1. Scientists produce human intestinal lining using micro-engineered organ chip

Epithelial cells from induced pluripotent stem cell–derived human intestinal organoids were incorporated into small microengineered Chips to produce 4 major intestinal epithelial subtypes that were biologically responsive to exogenous stimuli. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Walking movement of Embryonic stem cells studied

A detailed analysis of the migratory motion of human embryonic stem cells in two-dimensions has revealed that these cells move backwards and forwards along a preferred local direction to align with the axis of the cell elongation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Stem cell transplant improves survival for multiple myeloma patients- confirms study

Using data from two extensive California databases, it has been confirmed that autologous hematopoietic stem cell transplant improves survival for people suffering from multiple myeloma but many potentially eligible patients never undergo the procedure. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Astrocyte based Cell Therapy for ALS Patients enters human clinical trials

Astrocytes derived from human embryonic stem cells have delayed disease onset and prolonged survival and muscular activity of mice and rat models of Amyotrophic Lateral Sclerosis (ALS). This has led to a Phase 1/2a clinical trial to test the safety and effectiveness of this cell therapy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Poised pluripotency- A new state profiled in embryonic stem cells

Stem cell researchers have, for the first time, profiled a highly elusive kind of stem cell in the early embryo "the poised pluripotent stem cell"— a cell that it makes its entrance and exit within a 12-hour span.Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Niche of Intestinal stem cells identified.

Scientists have now discovered that cells called Gli1-positive cells which surround the crypts in the epithelium actually provide the signals for the colonic stem cells and hence, these Gli1-positive cells form the stem-cell niche. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. CRISPR gene editing may cause cancer- report studies

Genome editing by CRISPR–Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Therapeutic epicardial reservoir to aid regenerative cardiac therapies

Sustained delivery of cells using an epicardial reservoir in a myocardial infarct rodent model provided functional benefits in ejection fraction, fractional shortening and stroke work compared to single delivery of cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Researchers engineer artificial human bone marrow tissue

A 3D engineered human bone marrow has been developed in vitro using a bone-like scaffold functionalized by human stromal and osteoblastic cells. This artificial bone marrow has mimicked compositional and structural features of native human BM while supporting the maintenance of hematopoietic stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. 3D bioprinting of a cornea accomplished using an in-house collagen-based bio-ink

An in-house collagen-based bio-ink containing encapsulated corneal keratocytes have been used to bioprint corneal structures that resembled the structure of the native human corneal stroma. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that current treatment for mental health disorders may actually worsen symptoms in left handers? A study has shown that the location of a person's neural systems for emotion depends on whether they are left-handed, right-handed or somewhere in between. Therefore, current treatments which are designed for right-handers that stimulate their left-brain may actually worsen the symptoms in left-handers.
 -ScienceDaily, 18 June 2018 and Philosophical Transactions of the Royal Society B: Biological Sciences, 2018; 373 (1752): 20170141

2. Genetic studies have now answered a long standing question on why males' genetic diversity of their Y chromosomes collapsed 7000 years ago, the event termed as "Neolithic Y-chromosome bottleneck. It was the result of generations of war between patrilineal clans, whose membership is determined by male ancestors.
-Source: ScienceDaily. ScienceDaily, 29 May 2018 and Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-04375-6

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