CURRENT STEM CELL NEWS

1. Population dynamics of blood stem cells quantified

Studying the population size and lifetime dynamics of haematopoietic stem and progenitor colonies directly in humans for the first time scientists have identified 129,582 spontaneous, genome-wide somatic mutations. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Metabolism determines fate of the embryonic stem cell cell

Research has showed that Lncenc1, a highly abundant long noncoding RNA is the one that regulates the transcription of glycolytic genes thereby maintaining the self-renewal of naive embryonic stem cells (ESCs). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. New bioink scales up stem cell bioprinting

Hydroxypropyl chitin (HPCH) has been utilized as a new type of bioink for scalable expansion of Human induced pluripotent stem cells (hiPSCs) yielding high cell yield, high pluripotency maintenance and uniform aggregation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Microenvironmental regulation of Stem Cell Development studied

Bone marrow (BM) perivascular stromal cells and vascular endothelial cells (ECs) have been observed to regulate blood stem cell maintenance in a dichotomous and complementary process.Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Cancer regenerating cells distinct from cancer stem cells discovered

Leukemic-regenerating cells (LRCs) that arise post-chemotherapy which are distinct from leukemic stem cells (LSCs) have been discovered to be the reason behind remission of leukemia. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Injury induced reversion in the intestinal stem cell niche

A study has reported that inflammation of the mouse small intestine results in dramatic loss of the resident stem cells, followed by de-differentiation of highly specialized secretory units called Paneth cells into stem cell like states. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Software to make Stem Cell Transplants for Leukemia Patients safe

A method that uses genetic sequencing and computer software has been developed to predict which genetic sequences in patients lead to a unique set of proteins at the surface of cancer cells which could in turn help engineering of donor immune cells to specifically target the proteins present in cancer cells without affecting the patient's normal cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. In vivo reprogramming technique to directly convert the open wound into new skin

Expandable epithelial tissues using in vivo reprogramming of wound-resident mesenchymal cells have been generated which helps the skin ulcers in mice to have efficient and rapid de novo epithelialization. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Immortality Switch for brain cancer deciphered

Disruption of the genetic switch GABPβ1L (β1L) has been found to induces telomere loss and death in mutant glioblastoma. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Skin Gene therapy to curb cocaine addiction

Skin epidermal stem cells edited using CRISPR to express an enhanced form of butyrylcholinesterase—an enzyme that hydrolyses cocaine has been found to protect mice from cocaine-seeking behaviour and cocaine overdose. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Though society encourages people to be more physically active, new research has revealed that human brain is innately attracted to sedentary behaviour which may be due to the evolutionary characteristic of "conserving energy essential for humans' survival, as it allowed us to be more efficient in searching for food and shelter, competing for sexual partners, and avoiding predators".
 -Source: ScienceDaily, 18 September 2018 and Neuropsychologia, 2018; 119: 68

2. Did you know that Intestinal bacteria can create an electric current? yes, experiments have shown that enterococci which can be found in the gastrointestinal tract of humans when placed at an electrode can give rise to an electric current by releasing electrons when the bacterium breaks down sugar     
-Source: ScienceDaily, 18 September 2018 and Biochemistry, 2018; 57 (30): 4597

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