CURRENT STEM CELL NEWS

1. New protein critical to produce iPS cells identified

A protein known as NKX3-1 has been identified to be a crucial factor for induced pluripotent stem cell reprogramming and this can replace OCT4 in mouse and human iPSC induction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Geometric cues to reprogram cells

It has been shown in a study that just confining adult cells in a specific geometric space for 10 days is enough to make them exhibit stemness and use of genes is not required. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. New cardiac stem cell therapy highly effective- suggests study

Transplanting cryopreserved human embryonic stem cell–derived cardiomyocytes (hESC-CMs) in macaque monkeys with large myocardial infarctions has resulted in significant enhancement of cardiac function. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Stem cells from tumour to treat muscular dystrophy

Muscle progenitors derived from adult cells of a teratoma have led to regeneration of muscle in muscular dystrophy. The cell also caused long-term maintenance of regenerated muscle and allowed muscle regeneration in response to subsequent injuries. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. CRISP-R based iPS cell production

Reprogramming of primary human skin fibroblasts into induced pluripotent stem cells (iPSCs) has been achieved using the gene editing technology known as using CRISPRa, which helps to activate endogenous OCT4, SOX2, KLF4, MYC, and LIN28A promoters resulting in cellular reprogramming. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Protein behind blood stem cells' heterogenicity revealed

A protein called Special AT-rich Sequence Binding Protein 1 (SATB1) has been revealed to be the protein behind differences in blood stem cells' self-renewal ability and the differences in the ability of blood stem cells to differentiate into the various lymphocytic lineages. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Stem cells of blood flukeworm explored

Researchers have identified several different types of stem cells that govern the complex life cycle of blood fluke and also identified a gene associated with the earliest development of the germline, from which gametes form. This research will be highly useful in developing potential treatments for the parasitic disease schistosomiasis, one of the developing world's worst public health cause of concern. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Using metabolism to kill cancer

Targeting the metabolism by blocking mitochondria and manipulating glucose to block a specific metabolic pathway scientists have observed that cancer stem cells get knocked out. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Cancer treating Drug protects against smoke-induced lung injury

A medication that stimulates the immune system to release more number of hematopoietic progenitor cells, or HPCs from the bone marrow into the bloodstream used to treat cancers like multiple myeloma and non-Hodgkin lymphoma, could help in producing protective effects against smoke-induced lung injury. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Stem cell based gene editing technique tool to assess heart disease risk

CRISP-R based genome-editing of iPSCs from a patient who was healthy but carried a hypertrophic cardiomyopathy (HCM)-associated genetic variant has helped researchers to develop precision medicine tools to assess heart disease risk . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know your first memory could actually be fictional? Yes, Researchers having conducted one of the largest surveys of people's first memories found that nearly 40 per cent of people had a first memory which is fictional but crucially, the participants of the survey remembering them doesn't know that the memory was fictional.
 -Source: ScienceDaily, 17 July 2018 and Psychological Science, 2018 DOI: 10.1177/0956797618778831

2. A latest research has reported that we did not stem from a single ancestral population in one region of Africa but rather human ancestors were scattered across Africa and largely kept apart by a combination of diverse habitats and shifting environmental boundaries. Millennia of such separation gave rise to human diversity and later mixing of humans ultimately shaped our species.     
-Source: ScienceDaily, 11 July 2018 and Trends in Ecology & Evolution, 2018; DOI: 10.1016/j.tree.2018.05.005

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