CURRENT STEM CELL NEWS

1. New type of stem cells from 2-day old embryo cultured in lab

A novel type of stem cells called expanded potential stem cells have been established from 2-day old mouse embryonic blastomeres with remarkable pluripotent features. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Study offers insight into hair development from skin

Studying the developmental processes in skin, scientists have obtained a molecular "how to" guide for driving individual skin cells to self-organize into organoids that can produce hair. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Cancer cells and yeast share common sugar fermentation characteristics – suggests study

An evolutionarily conserved mechanism behind Yeast and cancer cells sharing the unusual characteristic of favouring fermentation of sugar over respiration has been elucidated by scientists. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Bone marrow failure in deadly blood cancer traced to faulty fat cells

It has been identified that Acute myeloid leukaemia (AML) specifically disrupts the fat cell niche in the bone marrow which leads to bone marrow failure. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Cellular origin of skin cancer traced

Researchers have tracked down the cellular origin of cutaneous melanoma to the reprogramming and de-differentiation of melanocytes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Drug reversing diabetes strengthen bones by acting on stem cells

Diabetic mice when injected with a compound called TNP (2,4,6-trinitrophenol) had significantly more bone cells, fewer fat cells and greater overall bone area. This is because this drug makes mesenchymal stem cells to make bone cells instead of fat cells by acting against an enzyme. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Single gene to enhance cardiac repair

Gene overexpression of the cell-cycle activator CCND2 has been found to increase the proliferation of grafted cardiomyocytes which resulted in improved cardiac function and decreased size of the infarct after heart attack. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Human sperm stem cell development mapped

A study has identified crucial molecular pathways that accompany the transition of Human adult spermatogonial stem cells (hSSCs) from quiescence to proliferation and differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Blood stem cell transplantation combined with gene therapy offers hope for Cerebral Adrenoleukodystrophy

Injecting autologous CD34+ cells genetically modified with Lenti-D gene therapy has shown to improve the outcome in patients with Cerebral Adrenoleukodystrophy, an X-linked genetic disease . Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Genome packing affects differentiation ability of stem cells- identifies study

A study has identified that the ability of a stem cell to differentiate depends on what portions of its genome are available for activation, which in turn is controlled by the location of DNA in a cell's nucleus. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Researchers have identified the genes that are actually behind the diversity of human skin colours from a study on more than 2,000 Africans from ethnically and genetically diverse populations. Four key areas in the genome have been identified in this study correlating with skin colour differences and this study has further strengthened the proposed early migration event of modern humans out of Africa along the southern coast of Asia and into Australo-Melanesia and a secondary migration event into other regions.
 -Source: ScienceDaily, 12 October 2017 and Science, 2017 DOI: 10.1126/science.aan8433

2. Did you know that education increases your longevity? Yes, a major study of the genes related to longevity has found that education leads to a longer life, with almost a year added for each year spent studying beyond school. The same study has shown that body fat and other factors linked to diabetes also have a negative influence on life expectancy.    
-Source: ScienceDaily, 13 October 2017 and Nature Communications, 2017; 8 (1) DOI: 10.1038/s41467-017-00934-5

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