CURRENT STEM CELL NEWS

1. Platelet nanovesicles to help in targeted delivery of cardiac stem cells

In a rat model of myocardial infarction, platelet nanovesicle coated cardiac stem cells when injected were more retained in the heart than non-coated cardiac stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Alcohol damages and mutates stem cells – study shows

Alcohol can break and damage DNA within blood stem cells leading to rearranged chromosomes along with causing permanent alteration of DNA sequences within these cells, according to a recent study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. iPSCs coaxed to form functional skeletal muscle

Induced pluripotent stem cells (iPSCs) were coaxed into forming functioning human skeletal muscle which can serve as a platform for human muscle disease modelling and drug development. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Stem cells + Drug combination prove effective for Multiple sclerosis

Researchers have shown that combining low-dose methylprednisolone and IFN-beta-secreting mesenchymal stem cells (MSCs-IFN-beta) could reduce the severity of disease in a mouse model of multiple sclerosis (MS). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Lab created heart muscle patches tested in large animal for the first time

Large sized human cardiac muscle patches (hCMPs) have been created using cardiomyocytes, smooth-muscle cells, and endothelial cells derived from human induced-pluripotent stem cells (hiPSCs) employing a fibrin scaffold and growing the cells in a dynamic platform.Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. CAR – T cells for HIV

Chimeric antigen receptor (CAR) T cells being employed for treating cancer can also help to ultimately eradicate HIV according to a study done in a nonhuman primate model of AIDS. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Blood stem cell transplant shows positive outcome in scleroderma

Myeloablative autologous hematopoietic stem-cell transplantation has shown to result in long-term benefits in patients with scleroderma. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Human arterial endothelial cell precursors grown in large scale in vitro

Two transcription factors, MYCN and SOX17 have been used to expand in a large scale the precursors of human arterial endothelial cells and independent cell lines of such precursors have been found to differ in their capacity to undergo endothelial-to-mesenchymal transition (EndoMT) which is a hallmark event in a large number of vascular diseases and disorders. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Cilia essential for retinal pigment epithelium's function for vision – shows study

Scientists have identified that the retinal pigment epithelium (RPE) which is essential for the process of vision requires the help of another cell, the functional primary cilium for complete maturation and that defects in this maturation process of RPE precedes diseases like age-related macular degeneration (AMD). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. CRISPR technology used to covert endogenous skin cells into stem cells in vivo

Skin cells present in body of mice have been converted to stem cells inside the body itself by activating a specific gene in the cells using CRISPR technology. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that a musician's brain is different to that of a non-musician? Yes it has been discovered that making music needs a complex interplay of various abilities which correlates with strongly developed brain structures. Also, the brain activities differ depending on the style of the music.
 -Source: Science Daily and NeuroImage, 2018; 169: 383

2. The Life on Earth was dominated by microbes for roughly 4 billion years when multicellular life suddenly appeared. This dramatic diversification of animals was believed to be triggered by an increase of atmospheric oxygen. However, scientists have now challenged this belief by their finding in a study with which they state that transcription factors induced by low oxygen concentration is the one which provided the animals with control over cell stemness that in turn lead to their diversification.     
  -Source: Science Daily and Nature Ecology & Evolution, 2018

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