CURRENT STEM CELL NEWS

1. Metabolite to hasten stem cell differentiation identified

Scientists have identified that a metabolite called alpha-ketoglutarate when added to human pluripotent stem cells hastens their differentiation into neural cells at 5 percent to 40 percent higher rate. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Novel stem cell based system for screening drugs for rare cancers

Researchers have used human stem and progenitor cells to develop a genetically accurate model of the brain tumour called medulloblastoma and then used a computational methodology to identify drugs which can target them. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Stem cells for effective antibody delivery

Engineered Mesenchymal stromal cells (MSCs) have been used as gene delivery vehicles for antibody delivery enabling improved, single-dose prophylaxis against Venezuelan equine encephalitis virus (VEEV), a mosquito-borne pathogen. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. T-regulatory cells to suppress GVHD after allogeneic blood stem cell transplant

To suppress graft-versus-host disease (GvHD) after allogeneic blood stem cell transplantation, researchers have devised a novel strategy in which they have stimulated recipient mice to produce radiation-resistant host T regulatory cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Stem cell mapping to generate pure stem cells

Mapping of signals has helped in inducing pluripotent stem cells to differentiate into pure populations of nearly 12 cell types at a much faster rate. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Adult brain stem cells vulnerable to Zika- says study

In addition to effects on fetal development, it has now been found out in a mouse model that peripheral Zika exposure can infect adult neural stem cells also causing cell death and reduced proliferation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. iPS technology aids precision cardiovascular medicine

Study of patient-specific heart muscle cells derived from Human induced pluripotent stem cells (hiPSCs) has revealed that reprograming preserves patient-specific gene expression and this cell based platform can be used to predict drug-related heart damage. Click to read more... | Click here to view the link of the relevant publication

8. Neural stem cells control their own fate through DROSHA

Though adult neural stem cells possess multi-lineage differentiation potential, they normally do not do so. The molecular factor behind this phenomenon has been identified to be the protein DROSHA which acts as a barrier. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Raman scattering technology to identify pure stem cells

Raman scattering technology can help identify trace numbers of undifferentiated human pluripotent stem cells in a mixed cell population with a better sensitivity than flow cytometry. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Oct-4 and customization of embryonic stem cells' response to external cues

Mechanisms that use the gene Oct-4 can help embryonic stem cells to customize their response to external signals and Oct-4 is integral for tissue-specific responses, as per a new report. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. It was not previously known if animal life on earth expanded before or after increase of oxygen levels. A study in 2015 has reported that increase in oxygen levels started animal life rather than change in animal behaviour leading to oxygenation.    
 --Source:ScienceDaily, 18 December 2015 and Nature Communications, 2015; 6: 10157

2. The human brain is a disproportionately large one and scientists have now hypothesized that social comparisons and cognitive challenges associated with making decisions whether to help another member of the society or not led to this disproportionately large sized human brains over the course of evolution. This finding has implications in designing artificial intelligence systems.    
                 -Source: ScienceDaily, 12 August 2016 and Scientific Reports, 2016; 6: 31459

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