CURRENT STEM CELL NEWS

1. Fasting boosts stem cell function in intestine

A mere 24 hour fast augments intestinal stem cell (ISC) function in mice by inducing a fatty acid oxidation process which activates adult stem and progenitor cells improving the regeneration in intestine. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Cardiospheres – the new stem cell hope for heart disease

Cardiospheres (CSps) a form of cardiac stem cells when pre-conditioned with pericardial fluid , hydrogel packing and implanted into the pericardial cavity improved cardiac function and alleviated myocardial fibrosis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Blood vessel stem cells to treat hemophilia

CD157 has been identified as a marker of tissue-resident vascular endothelial stem cells (VESCs) and transplantation of VESCs rescued bleeding phenotypes in a mouse model of hemophilia. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Brain lining cells once believed to have neural stem cell function are not so really –study proves

High-fidelity genetic labeling and analysis of ependymal cells, a type of cells in the brain has revealed that contrary to earlier beliefs, Ependymal cells don't behave as neural stem cells or progenitors in vitro or in vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Gene edited stem cells help restore Factor IX in liver – Potential to treat liver related blood clotting disorders

Scientists have shown that both allogenic hepatocytes and gene corrected iPSCs from patients with hemophilia B can be used to restore factor IX thus developing a potential cell therapy for monogenic diseases of the liver.Click to read more...

6. Clinical study embryonic stem cell derived RPE patch in Age-related macular degeneration proves successful.

An RPE patch comprising a fully differentiated, human embryonic stem cell (hESC)–derived RPE monolayer on a coated synthetic basement membrane has helped improve vision in human patients with wet type of Age related macular degneeration (AMD). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Communication failure between organelles –key factor behind aging

A new study has explored the role of mitochondrial proteins in controlling the well-being of the cell through previously unknown communication links and in aging cells this communication has been found to deteriorate or fail. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. iPSC derived neural cell grafting helps treating spinal cord injury in pig

Transplantation of syngeneic and allogenic induced pluripotent stem cell-derived neural precursor cells into the spinal cord injured pig in the absence of immunosuppression has resulted in successful engraftment, long-term survival, and differentiation into mature neurons and glial cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. First clinical study of Autologous adipose derived stem cell for treating psoriasis reported

Cell fate tracking of the regenerative epidermis (RE) during zebrafish fin regeneration has shown how the cells contribute to the regeneration process and how a dynamic rearrangement of the epidermis occurs during and after regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Gut microbiota derived metabolite suppress neural degeneration – says study

Byproducts that gut microbes produce when they break down dietary tryptophan can cross the blood-brain barrier, activating an anti-inflammatory pathway that limits neurodegeneration, according to a recent study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. RNA could be used to transfer memory. In an experiment, scientists extracted RNA from the nervous systems of marine snails that received the tail shocks and injected them into seven marine snails that had not received any shocks. It was then observed that the snails that received the RNA from snails that were given the shocks behaved as if they themselves had received the tail shocks. Thus, this method of transferring memory can lead to new ways to lessen the trauma of painful memories and to restore lost memories.
 -Source: ScienceDaily, 14 May 2018 and eneuro, 2018; ENEURO.0038-18.2018

2. Did you know that the immune system and graying of hair is related? Yes, an unexpected link has been found between gray hair, the transcription factor MITF, and innate immunity. When the innate immune response is activated through a genetic mechanism or via exposure to viral infection, the MITF is also altered leading to significant melanocyte and melanocyte stem cell loss causing an increased number of gray hairs.     
-Source: ScienceDaily, 3 May 2018 and PLOS Biology, 2018; 16 (5): e2003648

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