CURRENT STEM CELL NEWS

1. Genetic profiling helps predict the patient's response to a stem cell transplant

Genetic profiling of 1514 patients with myelodysplastic syndrome (MDS) has revealed the molecular subgroups of patients which could help in prognostic decisions in those patients undergoing blood stem cell transplant. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. iPS cell based screens for drug discovery for rare blood disorders

Blood progenitor cells derived from iPSCs of patients with Diamond-Blackfan anemia (DBA) has helped in creating an in vitro drug screening model for the disease, to create promising therapeutics for the disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Role of Vitamin C and Amino acid in controlling stem cell pluripotency deciphered

Researchers have found that two metabolites, vitamin C and the amino acid L-Proline, are important players in the control of stem cell behaviour and their relative levels can induce naive and reversible primed pluripotency. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Novel fiber-on-fiber matrix for large scale production of pluripotent stem cells of high quality

A layered nano-on-micro fibrous cellular matrix mimicking the extracellular matrix known as "fiber-on-fiber (FF)" matrix has been developed which can help in increased expansion of human pluripotent stem cells with maintenance of normal chromosomes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. iPS derived brain cell 3D structures help study rare genetic neurological disorder

Skin cells from patients with Miller-Dieker Syndrome (MDS), a rare genetic disorder causing fatal brain malformations have been converted to iPS cells which has resulted in a disease in a dish model for studying about this fatal disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Human somite development study in vitro made possible with pluripotent stem cells

Somites, which are groups of cells that give rise to skeletal muscles, bones, and cartilage in developing embryos have been developed in vitro from human pluripotent stem cells (hPSCs)using an efficient protocol to study the process of somitogenesis. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Thyroid tissue engineered from stem cells

Scientists have discovered a method by which switching on and off a gene called Nkx2-1 for a short period was able to coax pluripotent stem cells to give rise to thyroid gland structures in the lab. Click to read more... | Click here to view the link of the relevant publication

8. Long term remission in multiple sclerosis possible with stem cell transplant – suggests study

Results of a new clinical trial on high-dose immunosuppressive therapy and autologous stem cell transplant in Multiple Sclerosis patients has shown that 69% of the participants had positive outcome without relapse. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Stem cell derived vesicle therapy shows promise in Glaucoma

Administration of vesicles known as exosomes derived from mesenchymal stem cells has promoted survival of retinal neural cells and regeneration of axons in a glaucoma model opening avenues for novel cell free therapies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Telomerase driven cancer stem cells heterogeneity explored

Following Telomerase activity with a fluorescent protein in cancer stem cells has thrown novel insights into sub-populations of cancer stem cells with high proliferative and non-proliferative capabilities. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Eating less can slow down aging is a known fact. Researchers have identified one of the possible mechanisms behind the process wherein they have identified that cutting down calories lowers production of ribosomes and gives them extra time to repair themselves thus maintaining quality thereby slowing the aging process.    
 -Source: ScienceDaily, 13 February 2017 and Molecular & Cellular Proteomics, 2017; 16 (2): 243

2. Did you know that the human brain can actually appreciate the musical sound of poetry independent of its literary meaning? Yes, in a recent study, when sentences with certain poetic construction rules were presented, the brain has shown to produce positive electrophysiological response.    
-Source: ScienceDaily, 17 February 2017 and Frontiers in Psychology, 2016; 7

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