CURRENT STEM CELL NEWS

1. Stem cell therapy could be effective for heart disease – A review of 23 clinical trials suggests

In a review that analyzed 23 randomized controlled trials on heart disease patients who received either bone marrow stem cell (BMSC) therapy, standard treatment or no treatment, it has been observed that BMSC therapy is effective as found from the data that 3% of people who received stem cell therapy died, compared with 15% of people who received standard or no treatment. Click to read more...

2. Human embryonic stem cells boost heart regeneration in macaques

In eight macaque monkeys, scientists have induced heart attack and then injected human embryonic stem cells. The results have shown that there was regeneration of tissue by up to 40% and the regenerated tissue achieved electromechanical coupling with the original host heart. Click to read more...

3. Stem cells from dental pulp converted to neuron like cells

In a novel study, stem cells from the teeth have been induced to develop into a complex network of brain-like cells. This study could be useful for treating brain disorders using patient's own stem cells .Click to read more...

4. First disease-specific pluripotent stem cell line created with two sets of chromosomes

A Type I diabetes patient-specific pluripotent stem cell line that has two sets of chromosomes (the normal chromosome number in human cells), has been created from skin cells using somatic cell nuclear transfer method with the aim of treating diabetic patients with their own insulin-producing cells in the future. Click to read more...

5. Scientists convert non-embryonic stem cells into cells of the eye

A research on treating cornea with non-embryonic stem cells was published in 2014 Two research groups have reported the development of eye cells from non embryonic stem cells. In one study cells from the front of the eye have been used to create induced pluripotent stem cells (iPSCs) which were then reprogrammed cells to retinal progenitor cells. In the other study layered retinal tissue was created using different types of stem cells by addition of a growth hormone, insulin-like growth factor (IGF). Click to read more...

6. Bioscaffold to support the regrowth of bone and other three-dimensional tissues

A novel thermogelling hydrogel has been developed for delivery of stem cells into skeletal defects for inducing bone regeneration. The unique feature is that the hydrogel can be degraded and eliminated from the body as new bone tissue forms and matures. Click to read more...

7. Patient stem cells used to make 'heart disease-on-a-chip'

Scientists have created stem cells carrying the TAZ mutations from the skin cells of Barth syndrome (an inherited cardiovascular disease) patients and these cells were then grown on chips lined with human extracellular matrix proteins to create organ on a chip model of the diseased human heart. Then the scientists employed genome editing to create the first tissue-based model of correction of a genetic heart disease. Click to read more...

8. "Schizophrenia beginning in the womb-Theory", supported by a stem cell related study

Using Induced Pluripotent stem cell technology, neural progenitor cells (NPCs) have been created from schizophrenia patients and these cells were observed to have poor migration capabilities. Further the observation that these early stage neurons have the features of the disease is in line with the popular theory that occurrences during pregnancy can lead to schizophrenia.Click to read more...

9. Epigenetic study offers insight into hematopoiesis and formation of leukemia

A pathway regulated by a gene called MLL1 (for Mixed Lineage Leukemia) has been indicated in the maintenance of normal blood stem cells and damage to the gene has been implicated in the development of leukemia, according to a recent study on epigenetics. Click to read more...

10. Stem Cell therapy proves successful in Multiple Sclerosis

A research team from California has shown in genetic engineered mice with Multiple Sclerosis -like that injected stem cells though rejected in the mice, a follow-up after two week showed that the mice regained the ability to walk. Click to read more...

Really???

1.Are you aware that the innate immune system or the non specific immune system is found in all classes of plant and animal life while the adaptive immune system or the specific immune system is found only in vertebrates? Also neoplasia or cancer has been reported far more frequently in vertebrates than in invertebrates. In invertebrates neoplasia remains mostly benign because of the relative inefficiency of the innate immune system is relatively in eradicating tumors which in turn do not establish a strong enough selective pressure. The vertebrate immune system which is capable of generating strong and specific anti-tumor responses ultimately results in the selection of tumor variants that escape immune surveillance and thus the cancer become more invasive.                           
                                                                                         (Source: Dev Comp Immunol. Sep 2010; 34(9): 915–925)

2. Did you know that the term epigenetics was coined by C. H. Waddington in 1942 as a portmanteau of the words epigenesis and genetics? Epigenesis historically was used to describe the differentiation of cells from their initial totipotent state during embryonic development. Waddington used the phrase "epigenetic landscape" as a metaphor to describe establishment of cell fates during development. He described that cell fates are similar to rolling of a marble wherein increasing irreversibility of cell type differentiation is similar to ridges rising between the valleys in which the marbles are travelling. Waddington's notion of the epigenetic landscape is now being employed in the context of systems dynamics state approach for studying cell-fate.           
                                                                                                                             (Source : Wikipedia)

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