CURRENT STEM CELL NEWS

1. Role of circadian rhythm in skin stem cells studied at a single-cell level

Scientists have studied the role of circadian rhythms in skin stem cells at a single cell level and have identified that the circadian rhythm shifts the timing of cell division so that stages which are very sensitive to DNA damage are avoided during a metabolic stage known as oxidative phosphorylation which produces free radicals that can cause DNA damage. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. "Dementia in a dish" model created using iPSCs helps identify new treatment strategy

'Dementia in a dish' model created using induced pluripotent stem cells from dementia patients carrying a GRN mutation has helped to understand that the GRN mutation causes the defect in brain cells formation by altering a signalling pathway known as the Wnt signaling pathway. This study will help to identify molecular targets for treating the disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Tissue-engineered small intestine replicates key characteristics of functioning human intestine – reports study

As an update to an earlier study which reported the generation of tissue engineered small intestine (TESI) from human and mouse donor tissue implanted into mice, a recent study has demonstrated that these mouse and human TESI contains cells and ultra structural components similar to a fully functioning healthy human intestine. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. A roadmap of stem cell reprogramming process developed

A new methodology based on time-course analysis has helped create roadmap of the reprogramming process from an adult cell to a stem cell. The roadmap revealed that during reprogramming some steps get reversed in an expected order but some steps resist change until late reprogramming. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Genetically coded probes helps study role of cell mechanics in stem cell reprogramming and differentiation

A group of researchers have merely used soft substrates instead of genetic factors to reprogram cells to stem cells. Further they have used genetically encoded probes to measure the mechanical forces in living cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Engineered Mesenchymal stem cells help reverse autoimmune diabetes

Mesenchymal stem cells have been engineered to bear the cell adhesion molecule called HCELL which will help them lodge into pancreatic islets. These engineered MSCs when injected into diabetic mice have helped in normalizing blood glucose levels as per a recent report. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. iPSC derived motor neurons help scientists study Motor Neuron Disease (MND)

Stem cells from skin samples of Motor Neuron Disease (MND) patients created using iPSC technology has helped scientists to understand that even before the motor neurons show any signs of damage, they actually lose the ability to contract due to changes in ion channels. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Stem cells and fibrin gel help repair damaged corneas

Initial results of a pilot study employing autologous limbal stem cells incorporated into a gel of fibrin transplanted into eyes of patients with corneal damage has shown positive outcome. Click to read more...

9. Gene modified stem cells help create HIV resistant immune system in mice

A recent study in immunodeficient mice has demonstrated that a near-purified population of human stem cells modified with genes to resist HIV infection has help generate a HIV resistant healthy immune system in these mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Fat stem cells produce antimicrobials that defend us against pathogens- reveals study

A new role for fat stem cells in the skin has been identified wherein they secrete an antimicrobial peptide called cathelicidin antimicrobial peptide, CAMP which has the ability to kill invasive pathogens. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that even in a single individual developed from a single fertilized egg, different cells in the body can have a different genetic make-up? This condition is termed as genetic Mosaicism and is due to several reasons including non-separation of chromosomes during cell division, lag in anaphase (a stage of cell division), mutations etc. In fact intersex conditions may also result due to Mosaicism in humans in which some cells of the body will be XX (female) while the rest will be XY (male).- Source: Wikipedia

2. With the 2014 Nobel Prize in Chemistry awarded to the development of super-resolved fluorescence microscopy which has great applications in biology, it will be unfair if we are not aware of the earliest microscopes used in the history of mankind. Did you know that in 2000 BCE itself, Chinese used water microscopes made up of lens and water to visualize the unseen. Giovanni Faber was the one who coined the name microscope for Galileo Galilei's compound microscope in 1625. However the major contribution was from Antonie van Leeuwenhoek who popularized microscopy as a technique.     - Source: Wikipedia

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