CURRENT STEM CELL NEWS

1. Injectable hydrogel to boost stem cell therapy in brain and retinal disorders

A research team has showed that an Injectable biomaterial based on hyaluronan and methylcellulose improves retinal photoreceptor cell integration into the adult retina and also helps in neural stem cell survival in adult brain. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Combination therapy involving embryonic stem cells and anti-diabetic drugs can reverse type 2 Diabetes – suggests study

A study has demonstrated that cell therapy using Human embryonic stem cell (hESC)-derived pancreatic progenitor cells combined with an antidiabetic drug effectively improves glucose tolerance in type II diabetic mice models. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Novel stem cell population at the junction of pluripotency and differentiation discovered

Researchers have discovered a novel induced pluripotent stem cell type designated as region-selective pluripotent stem cells (rsPSCs) and these stem cells were found to be in a more differentiated state compared to previously reported stem cells with more suitable characteristics for laboratory manipulation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. DNMT1- A gene essential for breast and cancer stem cell maintenance

It has been identified that a gene called DNMT1 is essential for breast stem cells maintenance and its deletion inhibits breast cancer formation by limiting the cancer stem cell pool. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Dying cells send survival signals to protect their parent stem cells - Astonishing discovery

Cells dying due to radiation exposure or chemotherapy send warning signals to their parent stem cells to protect them for future repopulation of the tissue according to a new study done on fruit fly stem cells. This knowledge could help in designing novel effective anti-cancer drugs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Micro RNA family which plays a key role in maturation of stem cells into adult heart cells identified

A study has proven that members of the let-7 micro RNA (miRNA) family are the best identified factors till date in promoting embryonic heart cells to grow into mature adult-like heart cells by acting on several key regulatory pathways. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Epilepsy promotes neural stem cell conversion to an inflammatory cell type- says study

In an epilepsy mouse model, scientists have discovered that neural hyper-excitation during epilepsy causes hippocampal neural stem cells to stop generating new neurons and instead convert to reactive astrocytes which promote inflammation and disrupt neural communications. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Bio-inert chemical inducing caspase-9 suicide gene to help control adverse effects of stem cells transplantation

By injecting T lymphocytes that can induce the expression of the caspase 9 suicide gene (iC9-T cells) and a bio-inert chemical that can activate the iC9-T cells, scientists have shown that it is possible to control the severe side effects such as graft versus host disease associated with haploidentical stem cell transplantation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Ulcer-causing bacteria manipulates stomach stem cells - possible link to gastric cancer

Helicobacter pylori which are the bacteria associated with stomach ulcers have been shown to grow as colonies deep in the glands of the stomach and they manipulate the Lgr5+ stem cells of the stomach causing them to proliferate more. This manipulation in the long term could contribute to the development of stomach cancer. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Complex signaling network in adult cell reprogramming explored

A new study suggests that a complex signalling network consisting of the mechanistic target of rapamycin complex 1 (mTORC1) and autophagy genes are involved in the reprogramming of adult cells to induced pluripotent stem cells and their balance determines reprogramming efficiency. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that some heart transplant recipients have reported them taking on the personalities of their donors though this is not accepted by several of the mainstream cardiologists? Several hypotheses have been put forward to offer an explanation including that these traits could somehow have got transferred along with the donor's cells or the changes may be due to the improvements in the outlook of the recipients who would earlier have suffered the effects of poor circulation due to a failing heart but it is future research which must throw more insight into this phenomenon.    
 - Source: http://www.slate.com/articles/news_and_politics/explainer/2012/03/ dick_cheney_heart_transplant_can_a_ new_heart_change_your_personality_.html

2. Only two DNA base pairs A-T and C-G have been reported so far in all life forms on earth. Did you know that recently scientists have engineered a bacterium with its genetic material containing an added pair of DNA bases? The pair was formed between the bases d5SICS and dNaM (d5SICS–dNaM) developed by these scientists and the study demonstrated that these base pairs could be imported into Escherichia coli (E-coli) and that the E-coli's replication machinery could accurately replicate a plasmid containing d5SICS–dNaM without affecting the E-coli's growth.    
   - Source: http://www.kurzweilai.net/scientists-create-new-lifeform-with-added-dna-base-pair and Malyshev DA et al. Nature 2014 May 15;509(7500):385-8

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