CURRENT STEM CELL NEWS

1. iPS based lab model for non-alcoholic fatty liver disease developed

An induced pluripotent stem (iPS) cells based in vitro model has been developed for investigating nonalcoholic fatty liver disease (NAFLD) and this model has been able to recapitulate the metabolic changes that occur in vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Distinct state of human pluripotency defined

New molecular criteria have been postulated to judge the pluripotency of laboratory-generated stem cells and the study has identified a distinct pluripotent state in humans which that the current laboratory stem cell generating protocols do not actually give rise to. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Pure colonies of 12 different specialized cell types developed from embryonic stem cells in lab

Stepwise map of the pathways leading from pluripotency to pure colonies of 12 different human cell types including bone, muscle, and heart has been studied for embryonic stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Repeated doses of drug boosts anti-tumour immunity after blood stem cell transplant – says study

Repeated doses of the immunotherapy drug 'ipilimumab' has been suggested to restore antitumor effect to prevent relapse of hematologic cancers after allogeneic hematopoietic stem-cell transplantation (HSCT), by immune checkpoint blockade. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Microfluidic large scale-integration chip to study hundreds of adipose stem cells at a time developed

An automated microfluidic large-scale integration platform in which more than one hundred adipose-derived adult stem cell cultures can be studied has been developed and this platform has helped in analysis of single-cell data. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. iPS cells to model autism in lab

Induced pluripotent stem (iPS) cells created from skin samples of patients with autism have been developed into neurons in the lab. These neurons displayed less activity compared to normal neurons but when the researchers added a growth factor called IGF1, the activity of these ASD neurons improved. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Highly sensitive Tattoo for stem cells helps in tracking them in vivo

A novel cell permeable and cell retentive dye dubbed as a tattoo for stem cells has helped researchers to monitor stem cells in unprecedented detail once they are in vivo. Click to read more... | Click here to view the link of the relevant publication

8. Neural stem cells grafted to aged brains with success

Neural stem cells when grafted into the hippocampus of young and aged rats were able to engraft efficiently into both young and aged hippocampi. Also even after 3 months of grafting the stem cells were able to retain their stemness. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Novel molecular technique to identify Cell of Origin of deadly blood cancer

Whole-genome profiling of open chromatin is a precise methodology to identify the tumour cell of origin in leukemia and this could be a valuable cancer biomarker according to a new study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Asymmetric T cell division dictates their efficacy in immunotherapy – identifies study

Asymmetric partitioning of mTORC1 activity during the generation of daughter cells from T cells determines if the daughter T cell is going to become an effector T cell or memory T cell and this could potentially affect the success of T cell based immunotherapy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1.Did you know that higher the variability of brain and higher the frequency with which the different parts of the brain connect with each other, higher is the IQ and creativity?.    
 --Source:ScienceDaily and Brain, 2016; aww143 DOI: 10.1093/brain/aww143

2. Researchers have discovered that obesity does not affect only the next generation but future generations too. In that study male mice which were obese transmitted the phenotype even to their grandsons putting them at significant risk of developing metabolic disease. This transmission was paternally inherited which is believed to occur by actions of sperm noncoding RNA.    
 -Source: Science daily and Molecular Metabolism, 2016; DOI:10.1016/j.molmet.2016.06.008

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