CURRENT STEM CELL NEWS

1. Induced pluripotent stem cells (iPSCs) derived from aging human cells give rise to long axons after transplantation in rat with spinal cord injury

Cells reprogrammed using Induced Pluripotent stem cell technology derived from an 86 year old man have been transplanted into spinal cord injury rat model. The transplanted cells developed long axons extending out of the lesion, reaching the brain and the olfactory bulb. Click to read more...

2. Researchers uncover cellular mechanism behind inability of blood-forming cells to maintain blood production in aged mice

A molecular machinery called Mini-chromosome maintenance helicase has been found to be at a heightened risk of loss of activity in aged blood forming stem cells. Researchers have discovered that though there is loss of activity in these aged stem cells, they still retain the ability to repair the DNA damage as efficiently as young stem cells. Click to read more...

3. Competition between two proteins governs self-renewal and differentiation ovarian germline stem cells (GSCs) in Drosophila

A Recent report has stated that in Drosophila melanogaster (fruit fly) the balance between two protein name Bam and COP9 proteins maintains the self-renewal and differentiation functions of ovarian germline stem cells (GSCs). Click to read more...

4. Factors modulating the senescence process in adipose-derived stem cells, compromising their clinical application studied

Senescence hampers the morphology and function of adipose derived stem cells formation. A team of scientists has described a few important factors which modulate the senescence process of these stem cells, which has clinical implication during application of these cells in peripheral nerve regenerative cell therapy.Click to read more...

5. 5-lipoxygenase (5-LO), the Achilles heel of leukaemic stem cells

Leukemic stem cells are often resistant to treatment. Researchers have found that the enzyme 5-lipoxygenase (5-LO) plays a significant role in the leukaemic stem cell survival. Inhibitors against the enzyme 5-LO would serve as potential candidates in cancer therapeutics.Click to read more...

6. Buddy cell - A prerequisite for hematopoietic stem cell formation - Zebra fish study reveals

While studying the muscle mutations in Zebra fish, researchers have observed that a buddy cell termed "Endotome" cell act as a cushion for the pre-hematopoietic stem cells during their conversion to fully fledged stem cells. Click to read more...

7. Key molecular pathway shared between aggressive breast cancer and mammary stem cells that promote lactation during pregnancy

It has been identified that a molecular signaling pathway that is involved in mammary stem cell activation during pregnancy which is needed for lactation is also involved with the development of aggressive breast cancer (often associated with pregnancy). They have found that the cell surface receptor - proteins beta-3 integrin also known as CD61 is a good marker for this signaling pathway.Click to read more...

8. Stroke patients demonstrate signs of recovery after stem cell treatment

In a pilot study on stem cells injected in brains of recent stroke patients, the patients demonstrated signs of recovery over a six-month period after treatment but the study could not conclude whether the improvement was exclusively due to the stem cell therapy. Click to read more...

9. Novel approach helps charter Chromatin state dynamics during blood cell formation from stem cells

A new study that has charted for the first time histone dynamics during blood development has been able to identify the exact DNA regulatory sequences and the various regulatory proteins that are involved in controlling stem cell fate during blood formation. Click to read more...

10. Stiffness of the extracellular matrix is a key factor in guiding stem cell differentiation - proves study

Bioengineers have shown that the stiffness of the extracellular matrix is an important factor influencing stem cell differentiation while the degree of tethering or varying the size of the pores in the matrix did not affect stem cell differentiation in that experiment. Click to read more...

Really???

1. Have you heard of the gene named Indy? It is the acronym for 'I'm not dead yet' and it is named so because mutated versions of the gene have shown to double the average life span of fruit flies though the result is a subject matter of controversy. The name owns its origin to a comic line in the comedy film "Monty Python and the Holy Grail".  (Source : Wikipedia)

2. Are you aware of the Golden rice which is a genetic engineered variety of the Oryza sativa rice developed to biosynthesize beta- carotene (precursor of Vitamin ) in the edible parts of rice. This rice differs by the addition of three beta-carotene synthesizing genes from its parental strain. The scientific details behind golden rice were published in the journal Science in 2000 and this was considered a significant breakthrough at the time of its discovery. In 2005 'Golden Rice 2' that is capable of producing 23 times more beta-carotene was reported. (Source : Wikipedia)

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