CURRENT STEM CELL NEWS

1. Spectroscopy to track fat stem cells during osteogenic differentiation

A novel method known as electrical cell-substrate impedance spectroscopy (ECIS) has helped track Human adipose stem cells (hASCs) when they proliferated and differentiated into bone and this could help understand the variability among hASC populations. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Results of Safety studies on parthenogenetic stem cell derived neural stem cells cells for Parkinson's disease published

A phase I clinical trial on using human parthenogenetic stem cell derived neural stem cells (ISC-hpNSC) for treating Parkinson's disease has been proven to be safe in Preclinical tumorigenicity and bio distribution safety studies. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. RNA generated iPS cell more safe- suggests study

Transient delivery of exogenous RNA is a safer reprogramming system to generate and edit human induced Pluripotent Stem Cells (iPSCs), as per a new study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. HDAC Inhibitors to eliminate resistant cancer stem cells

Histone deacetylases (HDAC) have been found to be necessary in maintaining the cancer stem cells (CSCs) and HDAC inhibitors have been proved to have the potential to eliminate stubborn reservoirs of breast and ovarian cancer stem cells (CSCs). Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. 'Bad Luck and Cancer' study challenged by new findings

A controversial study last year which reported that occurrence of cancer is mainly due to bad luck of random accumulation of genetic mutations. This finding has been challenged by a new study which says that though such random mutations do play a role in cancer, they may not be the primary contributor. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Allogeneic iPS cells treat damaged hearts in Monkeys

Major histocompatibility complex (MHC)-matched allogeneic iPS cells from one monkey when injected to five other monkeys with induced myocardial infarction has resulted in improved cardiac function without immune rejection. Click to read more...

7. Metabolic reconfiguration promoting MSC phenotype deciphered

Researchers studying connection between multi-cellular aggregation and stemness enhancement in Mesenchymal stem cells (MSCs) in vitro have observed crucial processes underlying aggregation-induced metabolic reconfiguration in reacquisition of primitive phenotypic properties in these cells. Click to read more... | Click here to view the link of the relevant publication

8. Endogeneous Stem cell manipulation for Temporomandibular joint repair

Even a single resident fibrocartilage stem cell (FCSC) in the Temporomandibular joint (TMJ) when manipulated can help in spontaneously generating cartilage, bone and even the bone marrow niche in a mouse. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Induced neural stem cells promote stroke repair in mice

Undifferentiated induced neural stem cells (iNSCs) when injected into a mouse model of ischemic stroke has resulted in significant functional recovery. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Comparison of human and chimpanzee neural progenitors throws light on brain development

Studying cerebral organoids or in vitro culture aggregates of neural progenitors from human and chimpanzees has provided insights into the subtle differences between the two which may have effects in human neocortex evolution. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Dietary restriction has beneficial effects on longevity which is a known fact. Now by studying roundworms, the mechanism behind this process has been shown to be increased rate of autophagy or cellular recycling in diet-restricted worms which preserves the intestinal integrity and has other beneficial effects contributing to longevity.    
 --Source:ScienceDaily, 14 July 2016 and PLOS Genetics, 2016; 12 (7): e1006135

2. Researchers have identified key processes behind why humans exactly have five fingers in each hand. The study showed that this pentadactyl or five finger state draws its effect from the transition from an aquatic environment to a terrestrial environment leading to transition from fin to limb. The pentadactyl state occurred by mutually exclusive expression of two genes Hoxa11 and Hoxa13. in fact our ancestors had more than five fingers in each hand.    
                 -Source:ScienceDaily, 5 October 2016 and Nature, 2016; DOI: 10.1038/nature19813

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