CURRENT STEM CELL NEWS

1. Mesenchymal Stem cell therapy to prevent and treat lung disease in preterm infants

A phase I clinical study that transplanted mesenchymal stem cells has been proven to be safe and feasible in preventing and treating bronchopulmonary dysplasia (BPD), a serious lung disease in preterm infants. Click to read more...

2. Fat stem cells for ear reconstruction in microtia

As a potential strategy to treat children with a missing or malformed ear in a condition called microtia, scientists have been researchers have been able to create cartilage on an ear shaped scaffold using stem cells from fat. Click to read more...

3. Multipoint stem cells (MSCs) transplanted in a collagen type I/III matrix proves effective in treating patients with large chondral knee defects

A 3-year follow-up study of patients with large chondral defects of the knee, in whom multipoint stem cells (MSCs) and a collagen type I/III matrix were transplanted has shown positive results with no adverse reactions. Click to read more...

4. Fully functioning three-dimensional liver tissue grown from adult mouse stem cells

Researchers from the University of Cambridge have developed Liver organoids or 'mini livers' from mouse stem cells and these liver organoids will prove useful for drug toxicity testing in vitro. Click to read more...

5. Potential protein target for treating triple-negative breast cancer identified

A new study has identified that a protein, SOCS3 which is responsible for activating an inflammatory pathway, does not turn off in breast cancer which results in an increase in cancer stem cells and this protein will be a highly useful target to combat triple-negative breast cancer . Click to read more...

6. Transcription factors help convert specific group of cells in the gut lining into beta-like cells

Using three transcription factors, Pdx1 (P), MafA (M), and Ngn3 (N), scientists have been able to convert a specific group of cells in the gut lining into beta-like cells and these cells can be used to treat patients with Diabetes in the future. Click to read more...

7. Novel reagent helps scientists study protein synthesis in stem cells

Employing a technique based on a modified antibiotic, called puromycin, that makes it feasible to see and measure the amount of protein, researchers have studied protein synthesis in adult stem cells for the first time and the study has given rise to exciting findings. Click to read more...

8. Stem cells improve left ventricular (LV) heart function in rats with simulated myocardial infarction

Transplanting human umbilical cord blood cells into rats with a simulated myocardial infarction (MI) has resulted in improvement of left ventricular (LV) heart function compared to those rats that did not receive the stem cells.Click to read more...

9. Mesenchymal progenitor cells (MPCs) discovered in the dermis of the skin

Scientists from Auckland have identified mesenchymal progenitor cells (MPCs), a novel cell type with stem cell like properties in the dermis of the skin and have reported that these cells have the ability to give rise to fat cells. Click to read more...

10. Role of antioxidant protein Nrf2 in muscle regeneration process explored

A recent study has reported that aged mice lacking a protein called Nrf2 that regulates the production of antioxidants in the body, showed poor stem cell regeneration after two weeks of endurance exercise stress on treadmills and this poor stem cell regeneration may hamper the recovery of lost muscle mass. Click to read more..

11. NK cell based Immunotherapy helps treat acute lymphoblastic leukemia

Autologous immune enhancement therapy (AIET) using Natural killer (NK) cells combined with chemotherapy and radiotherapy has helped achieve remission in a 15-year-old city girl suffering from acute lymphoblastic leukemia. Click to read more..

Really???

1. Did you know that the term " Regenerative Medicine " is believed to be first been coined by William Haseltine who is the founder of the Human Genome Sciences, a biopharmaceutical corporation and was first used by Leland Kaiser in an article on hospital administration published in 1992 which stated the " Regenerative Medicine " as ''A new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems."

2. Are you aware about the two fathered mice? Scientists from the University of Texas MD Anderson Cancer Center isolated foetal fibroblasts from a male (XY) mouse (Father 1) and using iPS technology created pluripotent stem cells. When 1% of these cells spontaneously lost a Y-chromosome, to become genetically female (XO), these (XO) cells were injected in female blastocysts (XX) to form female chimeras (X0/XX) by using surrogate mothers. Then when these chimeras mated with male mice (XY) (Father 2), some of the offsprings had genetic information from the original father and the mated male but not from the female blastocysts or the surrogate mothers giving rise to what can be termed as two fathered mice.
                                                                                                                                          Source – Wikipedia

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