CURRENT STEM CELL NEWS

1. Acidic environment can transform the adult cells to pluripotency- reveals groundbreaking study

Recently, a team led by Haruko Obokata from the Harvard Medical School, Boston in a ground breaking study have created pluripotent stem cells from adult cells without introducing any transcription factors but rather by exposing the adults cells to an acidic environment. Click to read more...

2. Novel mechanism governing brain stem cell proliferation discovered

A team of researchers from Max Planck Institute of Molecular Cell Biology and Genetics in Dresden have identified that a combination of extracellular matrix (ECM) and thyroid hormones is needed for basal progenitors in the brain to proliferate and produce the sufficient neurons for brain development . Click to read more...

3. Study identifies protein critical to hematopoietic stem cell function

A new study shows that a protein called Lis1 regulates the asymmetric division of blood stem cells and this asymmetric division is essential for the blood stem cells to form one daughter stem cell and another specialized cell. This study will be useful in shedding light on regulators of cell growth in normal development and in cancer. Click to read more...

4. Carbon nanotube based scaffold for growing human embryonic stem cells developed

Culturing human embryonic stem cells using animal proteins or human cells has its own disadvantages. To overcome these problems scientists have grown the embryonic stem cells using synthetic carbon nanotube scaffolds successfully. Click to read more...

5. Scientists develop protocol that permits mouse melanoma cells to grow readily in cell culture

A protocol has been developed by Dartmouth researchers which permits cell harvesting from melanoma tumors in mice and help these cells grow in culture. These cell lines will be useful to researchers who use mouse melanoma as a model system for their studies. Click to read more...

6. Study on Ikaros gene throws light on molecular details during early B cell development from blood stem cells

A team of scientists has analyzed in mice the role of a gene called Ikaros on early stage of B cell development from blood stem cells. The results showed that a defect in Ikaros function causes a block in the B-lymphopoiesis and prevents the development of mature B cells. Click to read more...

7. Histones to dramatically enhance generation of induced pluripotent stem cells(iPSCs)

A study, published in the journal Cell Stem Cell has shown that a duo of histone proteins called TH2A and TH2B increases the efficiency of iPSC cell generation about twentyfold. Click to read more...

8. Scientists discover signaling pathway behind development of prostate gland

In a first of its kind study researchers have discovered a 'signalling pathway' that helps differentiation of stem cells of the prostate gland into prostate tissue cells called basal cells and luminal cells and they have also identified that retinoic acid and male sex hormones regulate this process. Click to read more...

9. Study uncovers interactions between neurovascular bundles (NVB) and the mesenchymal stem cells located in these NVBs

A team led by Yang Chai of the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry has studied the neurovascular bundles (NVB) which are groupings of nerves and blood vessels intertwined throughout the body and they have found that these NVBs contain stem cell populations including mesenchymal stem cells. This study has also focused on the interactions between the NVBs and the stem cells. Click to read more...

10. Fluorescent probes to identify mutations and novel Gene editing technique to boost stem cell research

Scientists at the Gladstone Institute have designed a special fluorescent probe which has high sensitivity to detect mutations ad the team has employed an advanced gene-editing technique called TALENs in induced pluripotent stem (iPS) cells. This study in the future will help to boost stem cell research to reverse harmful mutations in these cells. Click to read more..

Really???

1. Did you know that the first conclusive evidence for the existence of cancer stem cells was in 1997 when Bonnet and Dick isolated in leukemic cells a subpopulation that expressed a marker called CD34, but lacked the CD38 marker? Further they showed that these CD34+/CD38- cells were capable of initiating the tumour in NOD/SCID mice that were histologically similar to the donor and this opened the doors to the world of cancer stem cells.

2. Are you aware that the era of cancer chemotherapy began when nitrogen mustard a lethal chemical warfare agent used by Germans in world war I was tested for its anti-cancer property? In 1943, Germans attacked a port in Italy which housed a ship containing nitrogen mustard gas sent by the US, resulting in release of the gas across the city and exposing military personnel and civilians to the gas. The autopsies of the victims by pathologists sent by US showed that there was profound lymphoid and myeloid suppression. This led the US to recruit two pharmacologists, Louis S. Goodman and Alfred Gilman who by their experiments altering the chemical form of the nitrogen mustard demonstrated that the chemically altered agent could be used to treat lymphoma.                                                                 
                                                                                                                                                      Source – Wikipedia

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