CURRENT STEM CELL NEWS

1. Embryonic stem cells prove useful in toxicity studies

Embryonic stem cells have been proven to be a more cost- and effort-efficient toxicology testing system based on a recent study in which they were used to study the effects of Bisphenol A or BPA on gene expression. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Liver cell population which can function as stem cells identified

Scientists have identified a new cell type in the liver, adjacent to the central vein in the liver lobule of mice which has the properties of both self-renewal and making new liver cells thus giving the solution to the long standing mystery of how liver cells regenerate. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. CRISPR- Gene editing technology helps identify protein crucial for human pluripotent stem cell renewal

The Gene editing technology CRISP-R has allowed to scientists to identify that the protein α-5 laminin is crucial for the survival and self-renewal processes of human pluripotent stem cells (hPSC).This study will help to manipulate scaffolds or synthetic culture environments to encourage this protein production for better hPSC renewal. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. First ever Genetically-enhanced stem cell therapy clinical trial for pulmonary arterial hypertension shows positive results

A first of its kind clinical trial in which autologous endothelial progenitor cells (EPCs) genetically engineered to produce greater amounts of nitric oxide were infused into the patients has shown positive results in terms of improved blood flow in the lungs enhanced ability to exercise and improved quality of life. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Protein regulating neuronal stem cell activity explored

A study has shown that the protein NFIX which regulates neuronal stem cell activity (NSC) also helps in NSC differentiation toward oligodendrocytes which are the cells that produce the myelin sheath surrounding the neurons. This knowledge will help in development of NSC-based therapies for demyelination. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Automated high-throughput production of iPSCs developed

Researchers have developed a high-throughput, robotic platform that automates and standardizes the production of iPSCs from skin biopsies with minimal manual intervention. The iPSCs thus produced were shown to be stable and of high quality. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Skeletal muscle fibers grown from embryonic stem cells

Skeletal muscle fibers have been grown from mouse embryonic stem (ES) cells without the introduction of transgenes or cell sorting. Further it was demonstrated that these ES cells also had the ability to form dystrophin +ve fibers in a mice model of muscular dystrophy. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Cell-cycle clock controls pluripotency- reveals study

A study has produced evidence on how differentiation of pluripotent cells is controlled by the cell cycle clock. Precisely, during the S and G2 phases of the cell cycle the embryonic stem cells resist differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Silk fibroin scaffolds used to grow salivary gland cells ex vivo

Silk fibroin scaffolds have been used to promote the ex vivo growth of salivary gland epithelial cells from rat salivary glands. This work will help to develop therapies for dry mouth caused due to certain medicines, radiotherapy, auto-immune diseases, aging and other factors.. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Comparative research between two types of stem cells identifies the better efficient one for retinal regeneration

Induced Pluripotent stem cells (iPSCs) derived from photoreceptor cells of the retina have been shown to be more efficient in producing differentiated retinal cells in vitro when compared with embryonic stem cells and skin cells derived iPSCs in a recent study. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware about the Endosymbiotic theory? It is an evolutionary theory which states that "cellular organelles developed as a result of engulfment of free living bacteria by other prokaryotes termed as endosymbionts". Mitochondria are believed to have developed by endosymbiosis of proteobacteria by other prokaryotic cells.         
 - Source: Scitable – Nature

2. Did you know when the first gene therapy trial was conducted in humans? It was in 1990 when a four year old girl was infused with gene corrected white blood cells for her genetic disease called adenosine deaminase (ADA) deficiency. The study was conducted at the NIH, USA. As of 2014 nearly 2000 gene therapy clinical trials have either been conducted or approved throughout the world.    
                                                    -Source:http://history.nih.gov/exhibits/genetics/sect4.htm,                                                      http://www.wiley.com/legacy/wileychi/genmed/clinical

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