CURRENT STEM CELL NEWS

1. Mini Brains created in the lab using cells and 3D Culture system

In a first of its kind study, Harvard stem cell researchers have successfully grown vascular endothelial cells that line the blood vessels from human induced pluripotent stem cells (iPSCs) employing biomechanical cues.Cerebral Organoids or Mini brains have been created in the laboratory using neuroectoderm cell layer derived from established embryonic stem cells and Induced pluripotent stem cells (iPSCs) in a 3D scaffold employing a bioreactor. Click to read more...

2. Antibody against 'I – Antigen' generated - Potential to improve efficacy of isolation of mesenchymal stem cells from Umbilical cord blood

A novel recombinant antibody generated against the I antigen present on the mesenchymal stem cells (MSCs) can help to improve the identification and isolation of these cells from umbilical cord blood, according to a recent report. Click to read more...

3. Relationship between lamin-A, tissue stiffness and stem cell differentiation explored

Researchers have studied the relationship of Lamin-A, protein found in the cell nucleus and the differentiation of stem cells into stiffer and softer tissues. By growing mesenchymal stem cells (MSCs) in stiffer and softer substrates and changing the levels of Lamin – A production, these cells could be coaxed to form more bone tissue or more fat tissue in vitro.Click to read more...

4. Oligodendroglial progenitor cells (OPCs) with spiking properties created in vitro

A team of UC Davis researchers have created Oligodendrocyte cells with superior capabilities to form thicker myelin sheaths around the neuronal axons. This was done by introducing DNA that codes for sodium channels into embryonic stem cells derived Oligodendroglial progenitor cells (OPCs) which created better OPCs with spiking properties and this further produced the superior quality oligodendrocytes. Click to read more...

5. Induced Pluripotent stem cells repair heart muscle damage to re-establish correct cardiac synchronization in mice.

Synchronus pumping of the cardiac tissues is needed to improve the pump performance of the heart. Scientists have reported in the Journal of Physiology about the injection of induced pluripotent stem (iPS) cells in a murine model of myocardial infarction, where these cells synchronized the failing ventricles and helped in rescynchroniztion of the heart. Click to read more...

6. eTACs, a novel immune cell type with capability to prevent auto-immune disease

Scientists have discovered a novel type of dendritic cells called the Extrathymic Aire-Expressing Cells (eTACs) and have studied their role in a phenomenon called peripheral tolerance which could help prevent autoimmune disease. Click to read more...

7. Human umbilical cord blood derived mesenchymal stem cells to target Glioma – possible newer cell based delivery vehicles

A team of scientists led by Prof. Qingjun Zhang has identified that human Umbilical Cord derived Mesenchymal stem cells (MSCs) have excellent targeting capacity against glioma, which is a type of brain tumour and this characteristic of the MSC could make them useful cell based therapeutic agent delivery vehicles for this tumour. Click to read more...

8. Synthetic mRNA used in animal study to control the cell fate of cardiac progenitors

Injecting a synthetic mRNA that encodes for the growth factor VEGF-A has helped trigger the regeneration of progenitors present in the heart and enable them form cardiovascular tissue instead of fibrotic scar tissue in a study done on a mouse myocardial infarction model. Click to read more...

9. Targeted Drug delivery using neural stem cells and nanoparticles for aggressive brain tumour

Neural stem cells (NSCs) loaded with porous silica nanoparticles of the cancer drug doxorubicin when injected into mice with a brain tumour called Glioblastoma has extended the life of these mice by seven to eight days . Click to read more...

10. Role of Protein Mediator 'SON' in maintenance of human embryonic stem cells (hESCs) pluripotency explored

Based on a previous study of a genome-wide investigation of gene functions in human embryonic stem cells (hESCs), a team of scientists have reported the mechanism how a protein called 'SON' regulates the proper splicing of transcripts encoding the regulators of pluripotency in these cells thereby ensuring cell survival and maintenance of pluripotency . Click to read more..

Really???

1. Have you heard of the term called 'Lamarckism' in biology? It is the idea that an organism can pass the characteristics it acquired during its lifetime to its offspring. This is also termed as 'soft inheritance'. It is named after the French biologist Jean-Baptiste Lamarck . Recent works in the field of epigenetics have highlighted the possibility of soft inheritance.

2. Did you know that according to the discoverer of Penicllin, Sir Alexander Fleming, the first known reference to penicillin was from Psalm 51 which states: "Purge me with hyssop and I shall be clean"? Hyssop is considered as the plant mentioned as 'Ezov' in the Bible in the context of religious rituals. Sir Alexander Fleming had learned from the mycologist Charles Thom who helped him to identify the mould as Penicillium notatum , that this mould was first recognized by the Swedish pharmacist Per Richard Westling from a specimen of decayed hyssop.

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