CURRENT STEM CELL NEWS

1. Gene copies pair up during embryonic stem cell differentiation –identifies study

It has been identified in a recent study that the two alleles of Oct-4 gene which remain separate actually pair up transiently during the critical moment of embryonic stem cell differentiation into other cell types. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Successful cartilage repair using embryonic stem cells derived cartilage progenitors accomplished

Embryonic stem cells have been successfully converted to cartilage progenitors and implanted into damaged cartilage in the knee joints of rats. The results showed development of cartilage which was smooth akin to normal cartilage tissue, 12 weeks after implantation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Critical regulator of milk producing cells in mammals discovered

It has been identified that the protein MCL-1 is essential for the survival of the luminal cells that line breast ducts and hence are critical for milk production needed for the survival of mammalian species. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Assessing breast cancer cells' resemblance to normal stem cells helps in identification of aggressive breast cancer

A new study has suggested that testing how similar are breast cancer cells to normal stem cells could help predict the aggressiveness of the disease in breast cancer patients paving way for personalized treatments. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Skin cells converted to hypothalamic like neurons for the first time

Researchers have succeeded in converting skin cells using induced pluripotent stem (iPS) cell technology to hypothalamic like neurons. Hypothalamic neurons play an important role in several behavioral and basic physiological functions in the human body. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Treatment resistant stem cells present even in low grade tumours – reveals study

Cancer stem cells have been earlier reported for aggressive, fast-growing tumors. Now scientists have identified treatment resistant cancer stem cells even in a low grade brain tumour called neurofibromatosis type 1 (NF1). These cancer stem cells displayed unique molecular and functional properties. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Induced pluripotent stem cell (iPSC) technology and genome editing help create gene corrected cells from "bubble boy disease" patient

Scientists have employed iPS technology and gene editing technology to correct the faulty gene in the cells obtained from a Severe combined immunodeficiency disease (SCID) patient and these gene corrected iPS cells have been used to create healthy blood precursors and immune cells in the lab that will be useful in recreating a healthy immune system in such patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Super-resolution microscopes aid in study of stem cell pluripotency

STORM technique, a new super-resolution microscopy method has helped scientists study nucleosomes which are the most basic level of chromosome organization and it has been observed that there are important differences in the chromatin fibre architectures between stem cells and differentiated cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. iPS technology helps create cardiac microphysiological system (MPS) in vitro for drug testing

Pluripotent stem cells have been used to create a heart-on-a-chip device or a cardiac microphysiological system (MPS) which possessed an ability to beat on its own at a normal rate of 55-80 beats per minute and the device has been used to test four well-known cardiovascular drugs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. iPS cell derived neurons from Alzheimer's Disease patients help predict their response to therapy

Skin cells taken from Alzheimer's disease (AD) patients have been used to derive neurons and the study on these neurons has helped scientists explore the variants of the gene SORL1. Study of these SORL1 gene variants can help predict response to therapy in Alzheimer's disease (AD) patients. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know that genetic variants linked with autism are actually associated with higher intelligence or cognitive abilities in non-autistic individuals?    
 - Source: Clarke TK et al. Molecular Psychiatry, 2015

2. Are you aware of the term "Designer baby"? Designer baby refers to proposed use of pre-implantation genetic diagnosis methods to screen for desirable traits and thereby design traits like sex, hair color or intelligence according to needs using genetic techniques in an unborn baby.However this concept has raised several controversies.    
                                              - Source: Gordon JW. Science 1999 and Wikipedia

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