CURRENT STEM CELL NEWS

1. Successful iPS cell transplantation in genetically modified pig offers a new hope for human clinical studies

Rejection is a big hurdle for transplantation. To overcome the same scientists have developed a pig model with a modified immune system and when induced pluripotent stem cells were transplanted to the pig no rejection was noted. Click to read more...

2. Positive outcome obsevered in Phase I trial targeted against cancer stem cells using OMP-54F28

A Phase I trial using OMP-54F28 drug showed anticancer activity by targeting the wnt pathway of cancer stem cells and this trial showed positive results in most of the solid tumors. Click to read more...

3. Artificially grown human cartilage developed from human stem cells

Scientists from Columbia University have developed human bone cartilage from bone marrow derived stem cells for the first time in the laboratory and the cartilage was as robust as the native human cartilage. Click to read more...

4. New neuronal population within the subventricular zone (SVZ) neurogenic niche identified and explored

A previously unknown neuronal population that express the choline acetyltransferase (ChAT) enzyme has been identified within the subventricular zone (SVZ) neurogenic niche of the adult brain and using Optogentic tools it has been found that these ChAT+ cells instruct the stem cells to produce new neurons. Click to read more...

5. Study offers insights into Translation and Transcription during development in Drosophila

A Study on the changes occurring during the transition of oocyte to an embryo in Drosophila has revealed that translation of a set of roughly 60 mRNAs was upregulated without corresponding increase in the levels of protein produced. This implies that during this crucial period of induction of totipotency, transcription is absent. Click to read more...

6. Fasting before chemotherapy triggers stem cells to rejuvenate immune system

Results of a study has suggested that prolonged fasting before chemotherapy will trigger the dormant stem cells to an active state to form new immune cells and also it will help in minimizing the harmful effects of chemotherapy. Click to read more...

7. New method to study protein networks reveals key interaction behind embryonic stem cell differentiation

Employing synthetic proteins, scientist have simplified the method to study protein interactions and using the method, they were able to observe that a single protein interaction (between Grb2 and Ptpn11/Shp2 phosphatase) is sufficient to induce embryonic stem cell differentiation to other cell types.Click to read more...

8. Gene changes that occur during transition of naive embryonic stem cells to primed epiblast stem cells studied

By studying the shifts in gene transcription during the transition of stem cells from a naive embryo stage to a primed epiblast stage in mice, it has been identified that dormant distal enhancers of genes known as seed enhancers take up the primary transcriptional control. As these seed enhancers play vital role upto adulthood, studying them might be valuable to understand their role in human diseases. Click to read more...

9. Manipulating bone marrow stem cells using specific proteins converts them into brain cells - suggests study

A new method that works by manipulating a particular family of proteins called heparin sulfate proteoglycans has been found to be useful in converting bone marrow stem cells to brain cells. Click to read more...

10. Study advocates early prescription of G-CSF therapy to stimulate stem cell production in myocardial infarction patients

Researchers have suggested based on their study that injecting G-CSF that mobilizes stem cells, earlier than 37 hours following myocardial infarction and coronary intervention might be potentially beneficial. Click to read more...

Really???

1. Among genetically modified organisms, the development of the Blue Rose (actually Lavender or Mauve) deserves mention. A thirteen year hard work was responsible for the creation of this Blue Rose. The scientists of the collaborating organizations used three genetic alterations, adding two different genes and inferring a gene. One of the added genes was for the blue plant pigment "Delphinidin". The scientists used RNA interference (RNAi) technology to suppress the endogenous genes for color production thus blocking a crucial protein in color production and they added a variant of the protein that was blocked. This variant protein would not be blocked by the RNAi which will allow blue pigment formation by expression of the gene coding for "Delphinidin"(Source: Wikipedia)

2. Have you heard about cancer killing DNA robots? The structure of these nanorobots was designed using a open-source software, called Cadnano. Then the robots were built using DNA Origami. The built robots were barrel-shaped devices, which had 12 sites on the inside for attaching payload molecules and had two positions on the outside for attaching aptamers which are short nucleotide strands with special sequences that will recognize molecules on the target cells. Six combinations of aptamer locks, each of them designed to target different types of cancer cells in the culture were tested. In that study the aptamers which were designed against a leukemia cell could pick the leukemia cell from a mixture of cell types and since the aptamers have found their target, they act as clasps releasing the payload eg. An antibody designed against the leukemia cells.   (Source : http://www.nature.com/news/dna-robot-could-kill-cancer-cells-1.10047)

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