CURRENT STEM CELL NEWS

1. iPS derived liver cells help create 'Malaria in a dish' model

Using Induced pluripotent stem cells researchers have created a disease in a dish model of liver-stage of malaria infection. Using this model responses to antimalarial drugs can be studied. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Allogeneic stem cells successfully used to treat heart attack patients in first of its kind trial

A first of its kind trial using allogenic stem cells has been conducted in heart-attack victims in a Spanish hospital. Selecting allogenic samples is advantageous because donors whose cells will have the greatest potential for heart repair can be used. Click to read more...

3. Stem cell engineering helps create cells which may aid in brain tissue healing after radiation damage

Researchers have engineered stem cells to become oligodendrocytes and these cells have been injected into rats after radiation injury. They observed that these engineered cells help in the recovery of brain function compromised by the radiation injury. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Long term in vivo tracking of T memory stem cells in gene therapy patients accomplished

Patient who received genetically engineered T memory stem cells twelve years ago have been subjected to in-vivo tracking of cells. The result showed that stem cell clones were active for long term and they were also able to generate other type of cells like central memory and effector memory cells in-vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Chromosome shattering' results in spontaneous cure of rare immune disease

A recent study has reported that a WHIM syndrome (mutation occurring in a gene called CXCR4 leading to immune cell defects) patient experienced spontanoeus recovery due to deletion of the mutated portion of the gene by a genetic phenomenon called chromosome shattering or chromothripsis. It is suggested that the stem cell which would have undergone this genetic correction would have replaced the patient's neutrophils by healthy ones. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Stem cells prove effective than drug in multiple sclerosis trial

A comparative trial in multiple sclerosis patients has shown that patients who were injected stem cells had 80 per cent lesser new areas of brain damage than the patients who were treated with the drug called mitoxantrone. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. In vivo process of blood stem cell maturation visualized using genetic label based tracing

Using a fluorescent based tracking tool, researchers have been able to visualize in real time the process of formation of blood stem cells in mouse for the first time. It was found that it is not the stem cells which replenish the blood cells under normal conditions but rather it is the progenitor cells (which are produced by the stem cells) that go on to self-renew and differentiate but in a limited manner compared to stem cells. In times of need, the stem cells produce a couple of new first progenitors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. First of its kind regenerative knee surgery employing magnet to attract stem cells performed

In a novel technique, mesenchymal stem cells from bone marrow were extracted and coated with iron particles so that these stem cells when injected into a patient can be concentrated using an external magnet to concentrate them to the areas where they need to repair the cartilage injury. Click to read more...

9. Beating heart cells created in lab – Hopes to treat heart arrhythmias

Skin cells taken from a patient with heart arrhythmia (irregular beating of the heart) has been reprogrammed to heart cells and it was observed that these heart cells exhibited the same kind of arrhythmia in vitro. These cells can be used for testing treatments in the lab. Click to read more...

10. Molecular mechanisms behind cellular reprogramming explored

Researchers have been able to identify how mammalian cells develop specialized functions. The study revealed that this process is controlled by enhancer regions (a type of DNA "switch") and other key regulatory elements in the genome. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Did you know how the skin cells called Keratinocytes protect us from UV light? It is by their mechanism of taking up of melanosomes. The melanosomes are vesicles containing the light-protective pigment melanin which is then stored in the peri-nuclear area in the keratinocytes as "supranuclear caps". These supranuclear "caps" protects the DNA from UV light -induced damage

2. Are you aware that it is due to the shorter cycle of hair follicle growth taking only four months to complete that hairs in the eyebrow have much shorter length limit than hairs on the scalp which have a growth cycle of 3–4 years? These growth cycles are controlled by factors like epidermal growth factor, DLX3 etc.    
                                                                                                                                                     - Source: Wikipedia

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