CURRENT STEM CELL NEWS

1. Scaffolds to aid in homing of stem cells for in situ muscle tissue regeneration

In a recent study published, scientists have implanted muscle specific scaffolds in the leg of an animal to recruit stem cells in the body to the location of the scaffold so that the cells can contribute to muscle regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Modifying surface hardness alone can alter cell fate - New study reports

Researchers have demonstrated that by altering matrix stiffness alone, without addition of any cell fate modifying soluble factors it is possible to profoundly influence the stem cell differentiation. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Reduced ability of aged stem cells to repair damage, linked to JAK/STAT signalling pathway

It has been identified that the reduced function in aged muscle stem cells to repair/rebuild damage might be due to the progressive increase in activation of a signalling pathway called the JAK/STAT signalling pathway. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Mechanism behind therapeutic benefit of stem cells in acute respiratory distress syndrome (ARDS) revealed

Stem cells have been known to be therapeutically useful in treating acute respiratory distress syndrome (ARDS) and now it has been reported that this beneficial effect is by the promotion of the anti-inflammatory state in macrophage cells by these stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Antibody-studded iron nanoparticles employed to achieve targeted interactions between stem cells and injured cells in heart disease

Antibody studded iron nanoparticles have been employed to enhance heart repair, in which the iron nanoparticles were studded with two antibodies, one for therapeutic cells and one for the injured cells. The nanoparticles inside the body will bring the therapeutic cells close to the injured cells to help in repair and this can be further enhanced by magnetic attraction. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Bio-artificial liver successfully transplanted in rats and dogs

A bioartificial liver device made up of bone marrow and liver cells attached to biodegradable matrices has been created to treat liver failure and this device has been successfully tested on dogs and rats. Click to read more...

7. Stem Cells in the testis expressing biomarker protein called PAX7 hold key to fertility - suggests study

Rare stem cells in the testis that express the biomarker protein called PAX7 have been identified to act as progenitors and mature to fully differentiated sperm cells gradually and these rare stem cells are resistant to cancer therapies making them potential candidates to be used in therapy to treat infertility after cancer treatments. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Role of SIRT1 protein in maintaining blood stem cells' regenerative ability revealed

A study has reported that SIRT1 protein is needed for blood stem cells to stay healthy and blood stem cells without adequate SIRT1 resembled aged and defective stem cells which have the potential to become cancerous. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Huntington's disease pathology studied in the lab employing iPS based disease in a dish model

A disease in dish model of Huntington's disease (HD) has been created from skin and dental pulp cells of transgenic HD monkeys using iPS technology and the neurons derived using iPS were able to recapitulate the pathology of HD in the lab like developing intracellular and intranuclear aggregates of the mutant Huntington protein Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Researchers report novel technology to improve in vitro blood stem cell expansion

A novel method using fusion proteins have been used to expand blood stem cells in vitro and this method is advantageous as it does not involve any genetic modification. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that the term "Bioinformatics" was coined by Paulien Hogeweg in 1970 to refer to the study of information processes in biotic systems and Margaret Oakley Dayhoff is considered as the mother and father of bioinformatics? Margaret Oakley Dayhoff compiled one of the first protein sequence databases and she was the one who developed the one letter code for amino acids to reduce the datasize of files which were used to describe amino acid sequences in the era of punch-card computing - Source : Wikipedia

2. Did you know that a nanorobotic device termed Microbiovore has been designed to act as an artificial phagocyte cell to capture microorganism entering the body at the entry level itself? A microbiovore can internalize the bacteria and then the bacteria will be mechanically minced in an internal morcellation chamber followed by digestion using injection and extraction of preprogrammed sequence of 40 engineered enzymes and the bacterial cell is reduced to harmless substances which are discharged back to the blood stream - Source: http://www.rfreitas.com/Nano/Microbivores.htm

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