CURRENT STEM CELL NEWS

1. Crucial protein essential for stem cell homing and engraftment identified

It has been identified in a study that a protein named Klf5 is essential for proper homing and engraftment of the stem cells after bone marrow transplantation. In that study when the gene for klf5 was deleted in mice, the engraftment ability of the bone marrow stem cells was impaired. Click to read more...

2. Monoclonal antibodies to prevent Graft Vs Host disease after bone marrow transplant

Graft versus Host disease (GvHD) is an important adverse consequence of stem cell transplant. In order to prevent it, researchers have devised a novel technique in which they plan to use monoclonal antibodies which can specifically bind to the surface of immune cells that develop from the transplanted stem cells and prevent these immune cells from reacting adversely with the patient's tissue. Click to read more...

3. Immune system evading ability of a virus utilized to improve mesenchymal stem cell survival

Scientists have taken advantage of the immune system evading ability of human cytomegalovirus (HCMV) to modify the mesenchymal stem cells to produce the same proteins as the virus so that these cells can escape rejection by the immune system after transplantation thereby prolonging their survival and function inside the body.Click to read more...

4. Re-alignment of specific cancer inducing DNA in cancer stem cells may lead to prostate cancer- suggests study

As a means of uncovering the mechanism behind development of prostate cancer, It has now been discovered that prostate cancer stem cells undergo a DNA realignment which causes a specific cancer-associated gene within the cells to be inappropriately activated. This in turn triggers the stem cells to renew more often and this genetic modification also becomes permanent and is passed on from generation to generation. Click to read more...

5. Different Techniques to generate iPS cells re-visited

Telpalo-Carpio and team have published a comprehensive review of the methods employed by different teams around the world to change cell protein and gene profiles, along with its morphology and function, driving the cell to an induced pluripotent stem (iPS) cell state and this review will be a useful guideline for researchers working in this arena. Click to read more...

6. Cell as a remedial measure, vs a drug as a treatment tool; perspectives

Cell based therapies should be considered as procedures and not as drugs, suggests a recently published article in the journal Stem Cells and Cloning: Advances and Applications which has reviewed the different perspectives as to why cells should not be considered as drugs. Click to read more...

7. Fat cells to help in prolonged culture of human blood stem cells in the lab.

Growing human blood stem cells for longer periods in the lab is relatively difficult as these cells die off or tend to differentiate quickly. Offering a potential solution to this problem, a research team has employed fat cells as feeder layer for growing these human blood stem cells in lab for longer periods of time successfully. Click to read more...

8. Novel microfluidic device to advance pluripotent stem cell separation

Based on the fact that the adhesion properties of pluripotent stem cells are different from other cells, researchers have designed a micro fluidics based device for high throughput separation of these pluripotent stem cells including human induced pluripotent stem (iPS) cells (with as much as 99 percent purity) and embryonic stem cells. Click to read more...

9. Nerve cells that regulate appetite explored- Potential for treating obesity

A population of stem cells that are capable of generating new appetite-regulating neurons have been identified in the brains of young and adult rodents and this could help in designing strategies by which these cells can be manipulated in the future to tackle obesity. Click to read more...

10. Identification of adult stem cells in human intestinal tissue accomplished

Stem cells from intestine have earlier been studied in detail in mice. Now scientists at the University of North Carolina have been able to accomplish the identification of adult stem cells from human intestine using specific markers and they have also been able to identify two sets of stem cells, active ones and those in reserve. Click to read more..

11. Study identifies novel technique for engineering blood vessels with superior qualities

A common problem associated with lab engineered blood vessels is that they are leaky. Now a new study has studied the blood vessels created in lab by employing endothelial cells with three types of supporting cells namely lung fibroblasts, adult stem cells from fat and from bone marrow and also blood vessels which were formed with no support cells. The results showed that there were differences in the blood vessels depending on whether supporting cell is used and the type of cell used. Click to read more..

Really???

1. Have you heard about the ‘Good gene hypothesis’? It is an explanation in biology which suggests that the traits upon which females choose their mate are honest indicators of the male’s ability to pass on those genes that will produce good quality offsprings with better survival characteristics.

2. Among theories of origin of life, one that is becoming increasingly accepted is the Panspermia theory which suggests that life on earth was seeded from space. The theory proposes that life forms like bacteria get trapped in the debris that is ejected into space due to factors like collisions between planets that harbor life and these bacteria lie dormant until they land on a new planet and when conditions are ideal, these bacteria become active, start life and evolution in that planet.

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