CURRENT STEM CELL NEWS

1. Simple and Rapid method generates large numbers of lung stem cells for treating idiopathic pulmonary fibrosis (IPF)

A multicellular spheroid method has been used by researchers to generate large numbers of lung stem cells that have helped in reducing fibrotic thickening in pulmonary fibrosis in mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Chemically controllable gene to control human pluripotent stem cell differentiation

Scientists have developed a methodology which can regulate a single gene's behavior using chemicals. This method which employs CRISPR technique is useful in controlling differentiation of human pluripotent stem cell into endodermal lineages. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Accumulation of higher quantity of specific dipeptides in chronic myeloid leukemia (CML) stem cells points to potential therapeutic strategy

It has been shown in a recent study that stem cells of chronic myeloid leukemia (CML), a type of blood cancer accumulate higher levels of certain dipeptides compared to normal blood stem cells. These dipeptides are important for CML stem cell maintenance. Targeting these peptides could be a novel therapeutic strategy for CML. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Light based genetics employed to explore pluripotency network in embryonic stem cells (ESCs)

Light based induction of a gene Brn2 has been used to explore the pluripotency network in embryonic stem cells (ESCs) wherein researchers have been able to precisely control neural differentiation in the ESCs. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Emergency machinery bypasses routine lengthy process of blood stem cell differentiation to replenish platelets lost during inflammation

The platelet loss during infection is replenished by the body using a emergency bypass mechanism that bypasses the normal blood stem cell differentiation pathway causing cells called stem-like megakaryocyte-committed progenitors (SL-MkPs) to be activated resulting in production of more platelets. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Seemingly similar stem-cell programs differ between normal and cancer stem cells- reveals study

Cancer stem cells are responsible for tumour recurrence and metastasis. A research has shown that a process called epithelial-to-mesenchymal transition which leads to tumour dissemination though may appear to be similar in normal breast stem cells and breast cancer stem cells actually differs significantly in its details such as in the related master regulatory genes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Chemical free-technique helps induce differentiation of cardiac progenitors to cardiac muscle cells

A team of Scientists from London have created a silicon chip with grooves and these grooves stimulated a biochemical response in the heart stem cells grown in them causing the stem cells to become muscle cells of the heart. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Time lapse imaging reveals intrinsic differences between stem cells from two regions of the mouse brain

When scientists cultured stem cells found in two different areas of mouse brain using similar methods in vitro, time lapse imaging showed that these stem cells actually differed in their growth, movement and differentiation patterns. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Study demonstrates unexpected role for macrophages in the spermatogonial niche in the testis

A unique type of macrophages has been shown to form the stem cell niche for the stem cells of the testis in mouse. Also these macrophages have been observed to control the differentiation of these stem cells by expressing critical factors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal | Click here to view the link of the relevant publication in a peer reviewed journal

10. Embedding stem cells in hydrogels to boost bone repair

When mesenchymal stem cells (MSCs) were embedded in Injectable hydrogels and transplanted in small animal experiments, these hydrogels boosted bone regeneration compared to transplanting stem cells alone. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware that the term "Genetics" was coined by William Bateson, an English Biologist who used the term to describe the study of Heredity? Bateson was the one who greatly supported the principles of heredity discovered by Gregor Mendel and he also discovered the phenomenon of genetic linkage with Reginald Punnett. Along with Punnett, Bateson founded the Journal of Genetics in 1910. The term epistasis was also coined by Bateson.     
 - Source: J Genet. 2002 Aug;81(2):49-58 and Wikipedia

2. Did you know that Drosophila, one of the most favorite model organisms for biological research are one of the more advanced organisms on the earth at present due to their rapid evolution and frequent gene changes? Due to these factors since their genetic make-up differs greatly from other insects, it is actually difficult to use them for making comparisons in laboratory studies. Organisms like the beetle 'Tribolium' are more useful for such studies due to them retaining much of their ancestral DNA.    
  -Source:Wikipedia and Nucleic Acids Res. 2007 Jan;35(Database issue):D476-9

Creative Commons License All site content, except where otherwise noted is licensed under a Creative Commons Attribution 3.0 Unported License.