CURRENT STEM CELL NEWS

1. Adipose-derived stem cells possess resistance against chemotherapy drug- Potential for use in Cancer patients

Adipose derived stem cells have been found to possess resistance against the chemotherapy drug methotrexate (MTX) by increasing their dihydrofolate reductase levels. This finding has potential to improve healing after chemotherapy in cancer patients in the future. Click to read more...

2. Long term culture of embryonic like stem cells from Zebra fish without feeder layers accomplished

Retaining the pluripotency of embryonic stem cells in vitro is a challenging task. Scientists have derived embryonic like stem cells from Zebra fish and they have been maintained them without feeder layers for more than two years successfully in a study. Click to read more...

3. Endothelial colony-forming cells for mesenchymal stem cell engraftment

Co-transplantation of endothelial colony-forming cells (ECFCs) with mesenchymal stem cells (MSCs) have shown to improve the survival of the MSCs after implantation in mice and the improved survival permitted the MSCs to display increased regenerative potential in a recent study. Click to read more...

4. Study shows Nuclear transfer embryonic stem (ES) cells more closely resemble native ES cells than induced pluripotent stem (iPS) cells

Comparing stem cells created by Somatic cell nuclear transfer (SCNT) and Induced Pluripotent stem cells, it has been identified that Stem cells created by SCNT more closely resemble embryonic stem cells with fewer alterations in the gene expression and DNA methylation. Click to read more...

5. Stem cell derived tooth, a realistic possibility – suggests study

In the efforts towards growing teeth in vitro which needs epithelial-mesenchymal interactions, researchers have been so far able to use teeth epithelial adult cells with mesenchymal cells from embryos and also have been able to use embryonic epithelial cells with adult mesenchymal cells. Now they are working on possible sources to combine adult epithelial and adult mesenchymal cells.Click to read more...

6. Stem cells from Mediastinal fat tissue, discarded during surgery can be a potential source to treat heart failure- suggests study

A study done in an animal model has shown that stem cells collected from the mediastinal fat which is usually discarded during surgeries has cardioprotective effects and can be used to treat heart failure. Click to read more...

7. SUMO's role in the cancer cell growth explore

It has been reported that modification of a protein CDK6 by SUMO (small ubiquitin-like modifier) is a key mechanism required for the renewal and growth of the cancer stem cells in Glioblastoma. Inhibition of this process eliminated the cancer stem cells and lead to cancer growth suppression in that study.Click to read more...

8. Adult-derived human stem cells helps restore the corneal surface in limbal stem cell deficient mice

Scientists have successfully demonstrated the restoration of corneal surface in mice using human adult-derived ABCB5-positive limbal stem cells. They have reported that the gene ABCB5 acts as a marker for the corenal limbal and is essential for maintenance of the stem cells and for the growth and repair of the cornea. Click to read more...

9. Induced pluripotent stem cells from schizophrenia patients help understand genetic variations affecting brain cell development

Scientists by analysing neural progenitor cells created from the skin cells of Schizophrenia patients who had a part of 15q11.2 on one of their chromosomes missing have observed that these neural progenitor cells developed into an abnormal ring fashion. Studies like this will throw more light on mental health disorders like the Schizophrenia. Click to read more...

10. Role of geometry in stem cell development deciphered

Harnessing the utility of micropatterns etched using chemicals; researchers have been able to induce gastrulation process in embryonic stem cells. The cells which were not confined to the micropattern failed to form into layers. Click to read more...

Really???

1. Did you know that adult adipocytes' (fat cells) division is still debated? While studies before 1970's reported that adult adipocytes cannot divide but rather increase their size by lipid filling, studies in the 70's showed mixed results that fat cells cannot divide and that fat cells do divide. Recent studies have shown that expansion of adipose tissue occurs by differentiation of mesenchymal stem cells into pre-adipocytes which then give rise to adipocytes. However there are several unanswered questions till now. (Source: Lefterova, MI et al. Trends in Endocrinology and Metabolism 2009; http://www.stembook.org/node/561 and Cristancho AG, Lazar MA. Nat Rev Mol Cell Biol. 2011)

2. Are you aware of why sexual reproduction is preferred in biological evolution over asexual reproduction, though asexual reproduction is less energy and less time consuming? It is because genetic variations, overcoming harmful mutations and other factors that can favor natural selection and survival of species are all possible only with sexual reproduction.  (Source : Essay in theratchet.ca)

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