CURRENT STEM CELL NEWS

1. 'Ghost fibres' guide muscle stem cells to regenerate

Use of novel microscopic and imaging techniques have led scientists to observe that ghost fibers which are remnants of the old extracellular matrix left by dying muscle fibers actually guide the muscle stem cells into position for healing to begin. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Mesenchymal stem cells and Parathyroid hormone - An effective combination to regenerate bone

When a combination of mesenchymal stem cells and parathyroid hormone was injected into rats and pigs with vertebral fractures, there was enhanced stem cells' migration and increased formation of healthy bone in a recent experiment. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. New mode of stem cell regulation identified

A new study has demonstrated that stem cells manipulate their proliferative activity in response to different signals through the intracellular calcium (Ca2+) signaling pathway. Thus mechanisms which can control the intracellular Ca2+ concentration can be the master regulators of stem cell activity. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Study uncovers mechanism governing cancer stem cells reprogramming in tumour microenvironment

A team of researchers has studied cancer stem cells in chronic myeloid leukemia and have found out that the cancer stem cells enhance their capacity to self-renew and proliferate by switching to embryonic RNA splicing. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Retinal nerve cells grown from human embryonic cells using gene editing tool in lab

Researchers have used CRISP-R gene editing technology to make a cell line of human embryonic stem cells become fluorescent when they differentiate into retinal ganglion cells which will be potentially useful for application in Retinal ganglion cell (RGC) injury due to glaucoma and other forms of optic nerve disease. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Cell therapy approach to restore thyroid function studied

Researchers have studied the natural differentiation process in the thyroid by using mouse pluripotent stem cells. By stimulating the same pathways they have derived human thyroid progenitors from normal and disease-specific iPSCs from patients with hypothyroidism. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Skin cells to functional placenta generating cells conversion achieved

A team of scientists has introduced three genes Gata3, Eomes and Tfap2c into skin cells and the process converted the skin cells into stable and fully functional placenta-generating cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

8. Clinical grade embryonic stem cell lines screened

The molecular karyotype of 25 clinical-grade human embryonic stem cell lines has been studied and this study will be highly useful for developing pre-clinical and clinical trials on using these embryonic stem cells in regenerative medicine. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Gene editing technology helps create human cell-based lab model system for polycystic kidney disease (PKD)

CRISP-R gene editing technology has helped in guiding human pluripotent stem cells (hPSCs) to form kidney organoids which can recapitulate the features of polycystic kidney disease (PKD) in vitro. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Molecular switch which prevents CNS tumor development in Drosophila deciphered

Notch signaling determines cell fate. Studying the Drosophila it has been observed that a transcription factor protein, known as Eyeless blocks Notch signaling in the central nervous system which prevents tumor formation. Also it has been reported that aging neural progenitors lose their competence to respond to Notch signaling. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Are you aware of the first successful and approved nuclear gene transfer in humans? It was in 1989 when tumor-infiltrating lymphocytes (TIL) were gene modified to confer resistance to these cells for neomycin. These cells were infused as immunotherapy to five patients with advanced melanoma. The transduced gene served as a marker for the infused cells.    - Source: : Wikipedia and N Engl J Med. 1990 Aug 30;323(9):570-8

2. Do you know what Eugenics is? Eugenics refers to the set of beliefs and practices aimed to improve the genetic qualities of the human population. In spite of being a highly debated and controversial topic due to its negative association with the Nazi Germany, there are several types of Eugenic practices ranging from promoting higher rates of sexual reproduction for people with desired traits, sterilization of people with undesired traits etc. in existence from the ancient days and the latest gene editing techniques such as the CRISP-R which can make precise, targeted changes to the genome of living cells are also viewed as potential eugenic tools by its proponents.      -Source:Wikipedia

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