CURRENT STEM CELL NEWS

1. World's first human stem cell-based cellular model for muscular dystrophy developed

The cellular and molecular aspects during muscle development in a muscle disorder called facioscapulohumeral muscular dystrophy (FSHD) have been studied by employing the world's first pluripotent stem cell derived cellular model of five FSHD cell lines with four normal stem cell lines. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Recent progress in stem cell tracking documented

The current progress in tracking the transplanted stem cells in vivo such as reporter-gene based methods, exogenous contrast label-based methods and multimodel imaging methods have been summarized in a comprehensive review published by SuYing et al. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Transplantation dose affects stem cell behaviour in vivo- says study

By tracking blood stem cells after transplantation, it has been observed that differentiation of these stem cells changes with the transplantation dose and a high transplantation doses increases the number of stem cells which can produce short-term differentiating clones. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Plant regeneration offers crucial insights into stem cell biology

It has been demonstrated that plants during regeneration can naturally reconstitute their stem cells from adult cells by replaying embryogenesis. This study will serve to gain insights into human regeneration. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Mitochondrial replacement compromised by Genetic drift

Replacement of mitochondria by nuclear transfer between oocytes has been suggested as a strategy to prevent mitochondrial DNA related diseases. A study has now reported that though the mitochondrial DNA is replaced, the stem cell lines and derivatives from these oocytes have little carry-over of the transferred mtDNA and genetic drift may lead to restoration of original mtDNA genotype. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Study offers clue to why intestinal stem cells reside in crypts

The reason why intestinal stem cells reside in crypts had been a mystery. A study has offered clues to solving this mystery by suggesting that these stem cells reside in crypts to avoid contact with metabolites produced by gut microbiota which prevent proliferation of the stem cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

7. Stem cells can be useful to treat stroke- proves clinical study

In a clinical trial in which patients with chronic stroke were surgically transplanted with modified bone marrow–derived mesenchymal stem cells, the results have demonstrated significant improvement in the clinical outcome. Click to read more... | Click here to view the link of the relevant publication

8. Mice with longer telomeres created without genetic manipulations

A team of scientists has created mice in the laboratory with hyper-long telomeres and reduced molecular aging without using any genetic manipulations. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Role of laminin on muscle cell stemness in muscular dystrophy deciphered

Muscle-resident PDGFRβ+ cells have a dual role to play in muscular dystrophy. They both help and as well as compromise muscle regeneration. Studies in a mouse model has shown that a protein called laminin derived from these cells regulate the cells' stemness and laminin alone was able to partially reverse the muscle dystrophic phenotype in these mice. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. New bio-mimicry method for stem cell tracking developed

A biomimicry method has been developed by which it is possible to recover mesenchymal stem cells (MSCs) and the MSCs can be ex-vivo labeled with Ferumoxytol (without employing transfection agents and/or electroporation) so that these cells can be tracked in vivo. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1.Did you know that bacteria perfected their protein complexes more than 3.5 billion years ago? Using an ancestral sequence reconstruction method scientists have been able to study the ancient enzyme complexes in bacteria and the results showed that the enzymes were already sophisticated 3.5 billion years ago to a form as they exist today and this has occurred a mere 500 million years after life started on earth.    
 --Source:Science Daily and Cell Chemical Biology, 2016 DOI: 10.1016/j.chembiol.2016.05.009

2. It has been found that biological networks like the brain have evolved to be hierarchical with separate areas for processing different tasks because connections in biological networks are expensive to maintain and there is an evolutionary pressure to reduce the connections. This can be possible only if such biological networks are hierarchical..    
 -Source: Science Daily and PLoS Comput Biol 12(6): e1004829.

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