CURRENT STEM CELL NEWS

1. Cell surface sugar-proteins to isolate pure liver stem cell populations

To facilitate purification of pure populations of iPSC-derived hepatocyte-like cells, scientists have mapped the cell-surface N-linked glycoproteins that are present on primary hepatocytes. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

2. Small molecule to generate bone cells from iPSC

Using adenosine, a small molecule, researchers have managed to induce human pluripotent stem cells (hPSCs) to differentiate into bone forming cells and these bone cells helped repair cranial bone defects in mice without developing tumors. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

3. Clinical trial on IV Mesenchymal stem cells for chronic heart failure shows positive outcome

Heart failure patients injected with allogeneic mesenchymal stem cells intravenously in a clinical trial have shown improvement. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

4. Neural stem cell and molecule combination offers hope for stroke induced brain injury

In a study on mice model of stroke, combination of neural stem cells and a molecule 3K3A-APC has helped promote neural circuit restoration and improved functional recovery. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

5. Stem cell mutations and extrinsic factors cause cancer - says study on mulit-organ mapping of cancer risk

Multi-organ mapping of cancer risk has revealed that damage-induced activation of stem cells and extrinsic factors which enhance the proliferation of these cells markedly increases the cancer risk. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

6. Biomaterial study deciphers stem cells' perception of their niche

A study on a biomaterial has shown that interaction between the adhesive motif of a molecule called N-cadherin present on the stem cells and the RGD adhesive motif present on the biomaterial can alter the stem cells' perspective of the stiffening of the extracellular environment. Click to read more...

7. Link between Microcephaly and neural progenitors explored

A study has shown that the severity of microcephaly results not from defects in brain cells' division but due to the inability of neural progenitors to reach the cell division stage. Click to read more... | Click here to view the link of the relevant publication

8. Stem cell mechanism preserved across evolution revealed by study'

Study has shown that a stem cell specific alternative splicing (AS) mechanism earlier thought to be present only in mammals has been identified to be present in planarian stem cells too. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

9. Cellular barcoding to monitor stem cells

A cell barcoding technology has helped monitor blood stem cells at a single cell level in vivo and the study has thrown several insights into the developmental decline in regenerative potential of these cells. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

10. Bone marrow transplant without chemo, a possibility – suggests study

To avoid the use of chemotherapy before hematopoietic stem cell (HSC) transplant, scientists have employed a novel immunotherapy strategy which removes host HSCs from the bone marrow in preparation for a transplant. Click to read more... | Click here to view the link of the relevant publication in a peer reviewed journal

Really???

1. Brain's remarkable control of the senses has been highlighted in a recent study which has shown that when we need to concentrate on a specific task which requires sight, then the brain activity in the auditory cortex which controls hearing reduces. This knowledge will be useful in designing hearing aids and studying how impaired hearing can influence visual solving abilities.    
 --Source:Science Daily and Front. Hum. Neurosci., 18 May 2016

2. The long standing belief that that the length of human pregnancy is limited by the size of the birth canal and the human's ability to walk upright shortened the duration of gestation so that babies are born before their heads get too big has been refuted by a new study which has shown that it is mother's metabolism which limits human gestation length and women give birth just before they cross into a metabolic danger zone. This metabolic constraint explains why human babies are so helpless compared to other animals at birth. If humans have to give birth to a new-born with same developmental level as a chimpanzee, it would take a 16-month gestation which would place mothers in a metabolic zone well past their energetic limits.    
-Source:Science Daily and PNAS 2016;109(38):15212-216

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