Journal of Stem Cells and Regenerative Medicine
 
 
Vol.V  Issue: 2: (JSRM code: 005020700010)

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Our Experience with Autologous Bone Marrow Stem Cell Application in Dilated Cardiomyopathy.
Mukund K1, Keerthi N1, Arjun K.Nambiar1, Jayakrishnan AG*1, Senthilnagarajan R2, Murugan P2, Manjunath S2, Srinivasan V2, Abraham S2,3
(PASRM** 2009-007)

1. Omega Hospiatal, Mangalore, India. 2. Nichi-In Centre for Regenerative medicine, Chennai, India. 3. Yamanashi University - Faculty of Medicine, Chuo, Japan. .

 
     

Background - Use of autologous bone marrow stem cell is a newly evolving treatment modality for end stage cardiac failure as reported in the literature. We report our experience with two patients with dilated cardiomyopathy who underwent this treatment after failure of maximal conventional therapy.

Methods - A 29 year old Male patient with history of orthopnea and PND, with a diagnosis of dilated cardiomyopathy and echocardiographic evidence of severe LV dysfunction was referred for further treatment. His echo on admission showed EF of 17% and no other abnormal findings except elevated bilirubin levels. He was in NYHA functional class IV. He received intracoronary injection of autologous bone marrow stem cells in January 2009. 254X106 cells were injected with a CD34+ of 0.20%. His clinical condition stabilized and he was discharged home. He received a second injection of 22X106 in vitro expanded stem cells with a CD34+ of 0.72% in Aug 2009. He is now in NYHA class II-III with EF 24%.

A 31year old Male patient with history of increasing shortness of breath, severe over the past 3-4 days was admitted for evaluation and treatment. His echo on admission showed EF of 20% and was in NYHA functional class IV. Coronary angiogram was normal and he was stabilized on maximal anti failure measures. He received intracoronary autologous bone marrow stem cell injection of 56X106 with a CD34+ of 0.53% in August 2009. His clinical condition stabilized over the next 10 days and he was discharged home.

Conclusions - In our experience of two cases of dilated cardiomyopathy, safety of intracoronary injection of autologous bone marrow stem cells both isolated and in vitro expanded has been proven in both the cases with efficacy proven in one of the cases. Long term follow-up of these two cases and inclusion of more number of similar cases where all available conventional therapies have not resulted in significant improvement for such studies are planned.

** Proceedings of Annual Symposium on Regenerative Medicine

 
               
 

Dr.A.G.Jayakrishnan,MS,FRCSI,FRCS(C.T),
Cardio Thoracic Surgeon,
Cardiothoracic & VascularDepartment,
Mangalore, Karnataka, India
E-Mail: dr.jayakrishnan@gmail.com

         
                 
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